Gut motility in non-mammalian vertebrates as in mammals is controlled by the presence of
food, by autonomic nerves and by hormones. Feeding and the presence of food initiates …

The mechanism of action of drugs of abuse like cocaine and amphetamines has been
studied extensively in the dopamine terminal field areas of the caudate-putamen (CPu) and …

Two isoforms of the substance P (SP) receptor, differing in the length of the cytoplasmic
carboxyl-terminus by≈ 8 kDa, have been detected previously in rat salivary glands and …

The tachykinins form one of the largest peptide families in nature. In this review, we describe
the comparative features of the tachykinin peptides and their receptors, focusing particularly …

The TKs are a group of peptides widely occurring in mammalian and nonmammalian
tissues. As early as in the first publication on SP, the first compound of this group discovered …

RAFFA, RB, Possible role (s) of neurokinins in CNS development and neurodegenerative or
other disorders. NEUROSCI BIOBEHAV REV 22 (6) 789–813, 1998.—The present review is …

Substance P (SP) is a peptide neurotransmitter identified in many central and peripheral
neural pathways. Its precise role in human physiology has been difficult to elucidate. We …

Several lines of evidence implicate the neuropeptide substance P in depression, either in
the pathogenesis or as a novel target for amelioration of symptoms. NK1 (substance P) …

Tachykinins were purified from extracts of gastrointestinal tissues of the urodele, Amphiuma
tridactylum (three-toed amphiuma), and the elasmobranch Sphyrna lewini (hammerhead …

The involvement of tachykinin neuropeptides, such as substance P and the neurokinins, in
pain transmission is supported by a wealth of evidence. At present. the therapeutic potential …