Almost 60 years have passed since the initial discovery by Hubel and Wiesel that changes
in neuronal activity can elicit developmental rewiring of the central nervous system (CNS) …

Microglia have been recently shown to manifest a very interesting phenotypical
heterogeneity across different regions in the mammalian central nervous system (CNS) …

Microglia were first recognized as a distinct cell population in the CNS one century ago. For
a long time, they were primarily considered to be phagocytes responsible for removing …

Microglia are resident macrophages of the central nervous system and significantly
contribute to overall brain function by participating in phagocytosis during development …

Microglia rapidly respond to changes in neural activity and inflammation to regulate synaptic
connectivity. The extracellular signals, particularly neuron-derived molecules, that drive …

Microglia, the primary resident immune cell type, constitute a key population of glia in the
retina. Recent evidence indicates that microglia play significant functional roles in the retina …

Microglia are the brain's resident innate immune cells and also have a role in synaptic
plasticity. Microglial processes continuously survey the brain parenchyma, interact with …

Synapses are fundamental structures of neural circuits that transmit information between
neurons. Thus, the process of neural circuit formation via proper synaptic connections …

As the professional phagocytes of the brain, microglia orchestrate the immunological
response and play an increasingly important role in maintaining homeostatic brain functions …

The continuous crosstalk between microglia and neurons is required for microglia
housekeeping functions and contributes to brain homeostasis. Through these exchanges …