An important mechanism of posttranscriptional gene regulation in mammalian cells is the
rapid degradation of messenger RNAs (mRNAs) signaled by AU-rich elements (AREs) in …

Stress-activated signaling cascades are affected by altered redox potential. Key contributors
to altered redox potential are reactive oxygen species (ROS) which are formed, in most …

Stress granules (SGs) are dynamic cytoplasmic foci at which stalled translation initiation
complexes accumulate in cells subjected to environmental stress. SG‐associated proteins …

purpose. To investigate whether exposure of human corneal epithelial cells to hyperosmotic
stress activates the c-Jun NH 2-terminal kinase (JNK) stress-activated protein kinase (SAPK) …

Stabilization of mRNAs contributes to the strong and rapid induction of genes in the
inflammatory response. The signaling mechanisms involved were investigated using a …

Part of the cellular response to toxins, physical stresses and inflammatory cytokines occurs
by signalling via the stress-activated protein kinase (SAPK) and p38 reactivating kinase …

The cyclooxygenase (COX, prostaglandin endoperoxide synthase) is a key enzyme in
prostaglandin biosynthesis. Two isoforms of COX, COX-1 and COX-2, have been identified …

Glucocorticoids (GCs) are steroidal ligands for the GC receptor (GR), which can function as
a ligand-activated transcription factor. These steroidal ligands and derivatives thereof are …

Hyperosmolarity has been recognized to be a pro-inflammatory stress to the corneal
epithelium. The cell signalling pathways linking hyperosmolar stress and inflammation have …

Endothelial nitric oxide synthase (eNOS) is an important regulator of cardiovascular
homeostasis by production of nitric oxide (NO) from vascular endothelial cells. It can be …