The expression of Ki67 is strongly associated with tumor cell proliferation and growth, and is
widely used in routine pathological investigation as a proliferation marker. The nuclear …

The phenomenon of RNA interference (RNAi) which involves sequence-specific gene
regulation by small non-coding RNAs, ie, small interfering RNA (siRNA) and microRNA …

Distribution shifts—where the training distribution differs from the test distribution—can
substantially degrade the accuracy of machine learning (ML) systems deployed in the wild …

RNA interference (RNAi) is the process of sequence-specific, post-transcriptional gene
silencing in animals and plants, initiated by double-stranded RNA (dsRNA) that is …

Double-stranded RNA-mediated interference (RNAi) is a simple and rapid method of
silencing gene expression in a range of organisms. The silencing of a gene is a …

Highlights•Severe thrombocytopenia has been observed with a small number of antisense
oligos.•Peripheral neuropathy and mortality have been observed with an siRNA drug.•We …

Small interfering RNAs (siRNAs) are the mediators of mRNA degradation in the process of
RNA interference (RNAi). Here, we describe a human biochemical system that recapitulates …

Duplexes of 21–23 nucleotide (nt) RNAs are the sequence-specific mediators of RNA
interference (RNAi) and post-transcriptional gene silencing (PTGS). Synthetic, short …

RNA interference (RNAi) is a highly conserved gene silencing mechanism that uses double-
stranded RNA (dsRNA) as a signal to trigger the degradation of homologous mRNA. The …

Gene therapy offers great opportunities for the treatment of severe diseases including
cancer. In recent years the design of synthetic carriers for nucleic acid delivery has become …