[HTML][HTML] Heartworm disease–Overview, intervention, and industry perspective

S Noack, J Harrington, DS Carithers… - International Journal for …, 2021 - Elsevier
Dirofilaria immitis, also known as heartworm, is a major parasitic threat for dogs and cats
around the world. Because of its impact on the health and welfare of companion animals …

Microfluidic systems for cancer diagnosis and applications

S Akgönüllü, M Bakhshpour, AK Pişkin, A Denizli - Micromachines, 2021 - mdpi.com
Microfluidic devices have led to novel biological advances through the improvement of micro
systems that can mimic and measure. Microsystems easily handle sub-microliter volumes …

Caenorhabditis elegans as a model system for target identification and drug screening against neurodegenerative diseases

L Ma, Y Zhao, Y Chen, B Cheng, A Peng… - European Journal of …, 2018 - Elsevier
Over the past decades, Caenorhabditis elegans (C. elegans) has been widely used as a
model system because of its small size, transparent body, short generation time and lifespan …

The Role of Ca2+ Signaling in Aging and Neurodegeneration: Insights from Caenorhabditis elegans Models

J Alvarez, P Alvarez-Illera, P García-Casas, RI Fonteriz… - Cells, 2020 - mdpi.com
Ca2+ is a ubiquitous second messenger that plays an essential role in physiological
processes such as muscle contraction, neuronal secretion, and cell proliferation or …

Cell-based drug screening on microfluidics

J Zhai, S Yi, Y Jia, PI Mak, RP Martins - TrAC Trends in Analytical …, 2019 - Elsevier
With the inherent merits of a low reagent consumption, the small amount of sample needed
and easy integration, a wide variety of microfluidic platforms (continuous-flow, droplet, digital …

High-throughput behavioral screen in C. elegans reveals Parkinson's disease drug candidates

S Sohrabi, DE Mor, R Kaletsky, W Keyes… - Communications …, 2021 - nature.com
We recently linked branched-chain amino acid transferase 1 (BCAT1) dysfunction with the
movement disorder Parkinson's disease (PD), and found that RNAi-mediated knockdown of …

Microfluidic chambers using fluid walls for cell biology

C Soitu, A Feuerborn, AN Tan… - Proceedings of the …, 2018 - National Acad Sciences
Many proofs of concept have demonstrated the potential of microfluidics in cell biology.
However, the technology remains inaccessible to many biologists, as it often requires …

Fluorescence-based sorting of Caenorhabditis elegans via acoustofluidics

J Zhang, JH Hartman, C Chen, S Yang, Q Li, Z Tian… - Lab on a Chip, 2020 - pubs.rsc.org
Effectively isolating and categorizing large quantities of Caenorhabditis elegans (C.
elegans) based on different phenotypes is important for most worm research, especially …

Drug discovery technologies: Caenorhabditis elegans as a model for anthelmintic therapeutics

D Sepúlveda‐Crespo, RM Reguera… - Medicinal research …, 2020 - Wiley Online Library
Helminthiasis is one of the gravest problems worldwide. There is a growing concern on less
available anthelmintics and the emergence of resistance creating a major threat to human …

Studying Parkinson's disease using Caenorhabditis elegans models in microfluidic devices

K Youssef, A Tandon, P Rezai - Integrative Biology, 2019 - academic.oup.com
Parkinson's disease (PD) is a progressive neurological disorder associated with the loss of
dopaminergic neurons (DNs) in the substantia nigra and the widespread accumulation of α …