Insulin-like growth factor-I receptor and thyroid-associated ophthalmopathy

TJ Smith, JA Janssen - Endocrine Reviews, 2019 - academic.oup.com
Thyroid-associated ophthalmopathy (TAO) is a complex disease process presumed to
emerge from autoimmunity occurring in the thyroid gland, most frequently in Graves disease …

The IGF1 signaling pathway: from basic concepts to therapeutic opportunities

H Werner - International journal of molecular sciences, 2023 - mdpi.com
Insulin-like growth factor 1 (IGF1) is a peptide growth factor with important functions in
multiple aspects of growth, development and metabolism. The biological actions of IGF1 are …

Insulin-like growth factor-1 (IGF-1) and its monitoring in medical diagnostic and in sports

J Bailes, M Soloviev - Biomolecules, 2021 - mdpi.com
Insulin-like growth factor-1 (IGF-1) is the principal mediator of growth hormone (GH), plays a
crucial role in promoting cell growth and differentiation in childhood and continues to have …

[HTML][HTML] Poly-l-glutamic acid modification modulates the bio-nano interface of a therapeutic anti-IGF-1R antibody in prostate cancer

S Vicente-Ruiz, A Armiñán, K Maso, E Gallon… - Biomaterials, 2023 - Elsevier
Modifying biological agents with polymers such as polyethylene glycol (PEG) has
demonstrated clinical benefits; however, post-market surveillance of PEGylated derivatives …

2021 update on thyroid-associated ophthalmopathy

EJ Neag, TJ Smith - Journal of endocrinological investigation, 2022 - Springer
Purpose Our understanding of thyroid-associated ophthalmopathy (TAO, AKA Graves'
orbitopathy, thyroid eye disease) has advanced substantially, since one of us (TJS) wrote …

Insulin-like growth factor-1 receptor controls the function of CNS-resident macrophages and their contribution to neuroinflammation

DC Ivan, KC Berve, S Walthert, G Monaco… - Acta neuropathologica …, 2023 - Springer
Signaling by insulin-like growth factor-1 (IGF-1) is essential for the development of the
central nervous system (CNS) and regulates neuronal survival and myelination in the adult …

[HTML][HTML] It takes two to tango: IGF-I and TSH receptors in thyroid eye disease

L Girnita, TJ Smith, JA Janssen - The Journal of Clinical …, 2022 - ncbi.nlm.nih.gov
It Takes Two to Tango: IGF-I and TSH Receptors in Thyroid Eye Disease - PMC Back to Top
Skip to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI Homepage …

The actions of IGF-1 in the growth plate and its role in postnatal bone elongation

HL Racine, MA Serrat - Current osteoporosis reports, 2020 - Springer
Abstract Purpose of Review Bone elongation is a complex process driven by multiple
intrinsic (hormones, growth factors) and extrinsic (nutrition, environment) variables. Bones …

[HTML][HTML] IGF system targeted therapy: Therapeutic opportunities for ovarian cancer

JAL Liefers-Visser, RAM Meijering, AKL Reyners… - Cancer Treatment …, 2017 - Elsevier
The insulin-like growth factor (IGF) system comprises multiple growth factor receptors,
including insulin-like growth factor 1 receptor (IGF-1R), insulin receptor (IR)-A and-B. These …

Investigational IGF1R inhibitors in early stage clinical trials for cancer therapy

H Werner, R Sarfstein, I Bruchim - Expert opinion on investigational …, 2019 - Taylor & Francis
Introduction: The insulin-like growth factors (IGFs) are a family of secreted peptide hormones
with important roles in different cellular and organism functions. The biological activities of …