Strategies to improve the physicochemical properties of peptide-based drugs
Peptides are a rapid-growing class of therapeutics with unique and desirable
physicochemical properties. Due to disadvantages such as low membrane permeability and …
physicochemical properties. Due to disadvantages such as low membrane permeability and …
[HTML][HTML] Characterization and Functionalization Approaches for the Study of Polymeric Nanoparticles: The State of the Art in Italian Research
Polymeric nanoparticles (PNPs) are a group of nanocarriers employed in a wide range of
applications. Characterization is a fundamental step in PNPs formulation and many basic …
applications. Characterization is a fundamental step in PNPs formulation and many basic …
Nanotechnology in targeted drug delivery
A Di Stefano - International journal of molecular sciences, 2023 - mdpi.com
The use of large sized materials in drug delivery raises several challenges, including in vivo
stability, poor bioavailability/solubility/absorption, and issues with target-specific delivery, in …
stability, poor bioavailability/solubility/absorption, and issues with target-specific delivery, in …
Formulation and evaluation of pravastatin sodium-loaded PLGA nanoparticles: in vitro–in vivo studies assessment
SI Elsayed, GNS Girgis… - International Journal of …, 2023 - Taylor & Francis
Purpose Pravastatin sodium (PVS) is a hypolipidemic drug which suffers from extensive first-
pass metabolism and short half-life. Poly (d, l-lactide-co-glycolide)(PLGA) is considered a …
pass metabolism and short half-life. Poly (d, l-lactide-co-glycolide)(PLGA) is considered a …
Polymeric nanoparticles decorated with fragmented chitosan as modulation systems for neuronal drug uptake
H Hernández-Parra, H Cortés, A Romero-Montero… - Carbohydrate …, 2024 - Elsevier
This study aimed to modify chitosan (CS) by gamma irradiation and use it as a surface
coating of nanoparticles (NPs) fabricated of poly lactic-co-glycolic acid (PLGA) to create …
coating of nanoparticles (NPs) fabricated of poly lactic-co-glycolic acid (PLGA) to create …
Nanomaterials Regulate Bacterial Quorum Sensing: Applications, Mechanisms, and Optimization Strategies
C Hu, G He, Y Yang, N Wang, Y Zhang, Y Su… - Advanced …, 2024 - Wiley Online Library
Anti‐virulence therapy that interferes with bacterial communication, known as “quorum
sensing (QS)”, is a promising strategy for circumventing bacterial resistance. Using …
sensing (QS)”, is a promising strategy for circumventing bacterial resistance. Using …
[HTML][HTML] Polyethylene Glycol-Modified Cationic Liposome as a Promising Nano Spray for Acute Pneumonia Treatment
K Wang, D Chen, C Zhang, L Lu, F Shang, Y Li - Polymers, 2024 - mdpi.com
Acute pneumonia (AP), triggered primarily by pathogens like bacteria and viruses, is a
leading cause of human mortality. Ribavirin, a broad-spectrum antiviral agent, plays a …
leading cause of human mortality. Ribavirin, a broad-spectrum antiviral agent, plays a …
[HTML][HTML] Current updated review on preparation of polymeric nanoparticles for drug delivery and biomedical applications
H Bhardwaj, RK Jangde - Next Nanotechnology, 2023 - Elsevier
Polymers show a vast possibility of chemical modification of novel properties and
nanomedicine generation in biomedical fields. Polymeric nanoparticle (PNPs) is commonly …
nanomedicine generation in biomedical fields. Polymeric nanoparticle (PNPs) is commonly …
LAT1 targeted brain delivery of temozolomide and sorafenib for effective glioma therapy
Y Zhang, Q Cheng, Y Xue, K Yao, MZ Syeda, J Xu… - Nano Research, 2023 - Springer
Glioma is the most common primary craniocerebral tumor caused by the cancerous growth
of glial cells in the brain and spinal cord. Currently, standard treatment is the surgical …
of glial cells in the brain and spinal cord. Currently, standard treatment is the surgical …
Predicting nanocarrier permeation across the human intestine in vitro: Model matters
N Jung, J Schreiner, F Baur, S Vogel-Kindgen… - bioRxiv, 2024 - biorxiv.org
For clinical translation of oral nanocarriers, simulation of the complex intestinal
microenvironment is crucial to evaluate interactions and transport across the intestinal …
microenvironment is crucial to evaluate interactions and transport across the intestinal …