A major obstacle to the development of medications for nicotine dependence is the lack of
animal and human laboratory models with sufficient predictive clinical validity to support the …

This review focuses on nicotine comorbidity in schizophrenia, and the insight into this
problem provided by rodent models of schizophrenia. A particular focus is on age …

Increasing evidence suggests that enhanced dopamine (DA) neurotransmission in the
nucleus accumbens (NAc) may play a role in mediating the reward and reinforcement …

The γ-aminobutyric acid (GABA)-B receptor agonist baclofen is known to reduce drug intake
in both animals and humans and to prevent reinstatement of cocaine-, opioid-, and alcohol …

Nicotine is a psychomotor stimulant with 'reinforcement enhancing'effects—the actions of
nicotine in the brain increase responding for non-nicotine rewards. We hypothesized that …

Preclinical drug discrimination techniques play a significant role in advancing our
knowledge of the receptor mechanisms underlying the interoceptive effects of nicotine. Early …

Dopaminergic afferents from the mesencephalic areas, such as ventral tegmental area
(VTA), synapse with the γ‐aminobutyric acid (GABA)‐ergic interneurons in the prefrontal …

Nicotine reinforcement is important for the initiation of smoking behavior. In addition,
incentive motivation, or the ability of environmental cues to drive behavior, may play a …

There are a number of approved therapeutics for the management of alcohol dependence,
which might also convey the potential as smoking cessation aids. The present study …

Rats reared in an enriched condition (EC) display less sensitization to nicotine than rats
reared in an impoverished condition (IC). However, it is unknown what effect differential …