The role of metabolism in the pathogenesis of osteoarthritis
Metabolism is important for cartilage and synovial joint function. Under adverse
microenvironmental conditions, mammalian cells undergo a switch in cell metabolism from a …
microenvironmental conditions, mammalian cells undergo a switch in cell metabolism from a …
Cartilage diseases
Y Krishnan, AJ Grodzinsky - Matrix Biology, 2018 - Elsevier
Hyaline cartilages, fibrocartilages and elastic cartilages play multiple roles in the human
body including bearing loads in articular joints and intervertebral discs, providing joint …
body including bearing loads in articular joints and intervertebral discs, providing joint …
Hip osteoarthritis: etiopathogenesis and implications for management
Highly prevalent among the elderly, hip osteoarthritis (OA) carries a heavy burden of
disease. Guidelines for the management of hip OA are often extrapolated from knee OA …
disease. Guidelines for the management of hip OA are often extrapolated from knee OA …
Monocytes, macrophages, and their potential niches in synovial joints–therapeutic targets in post-traumatic osteoarthritis?
Synovial joints are complex structures that enable normal locomotion. Following injury, they
undergo a series of changes, including a prevalent inflammatory response. This increases …
undergo a series of changes, including a prevalent inflammatory response. This increases …
[HTML][HTML] Chondrocyte and mesenchymal stem cell-based therapies for cartilage repair in osteoarthritis and related orthopaedic conditions
Osteoarthritis (OA) represents a final and common pathway for all major traumatic insults to
synovial joints. OA is the most common form of degenerative joint disease and a major …
synovial joints. OA is the most common form of degenerative joint disease and a major …
Homeostatic mechanisms in articular cartilage and role of inflammation in osteoarthritis
X Houard, MB Goldring, F Berenbaum - Current rheumatology reports, 2013 - Springer
Osteoarthritis (OA) is a whole joint disease, in which thinning and disappearance of cartilage
is a critical determinant in OA progression. The rupture of cartilage homeostasis whatever its …
is a critical determinant in OA progression. The rupture of cartilage homeostasis whatever its …
[HTML][HTML] Mimicked hybrid hydrogel based on gelatin/PVA for tissue engineering in subchondral bone interface for osteoarthritis surgery
A Thangprasert, C Tansakul, N Thuaksubun… - Materials & Design, 2019 - Elsevier
Osteoarthritis (OA) is a degenerative joint disease of the articular cartilage and extends to
the subchondral bone. The interface between these soft and hard tissues has a significant …
the subchondral bone. The interface between these soft and hard tissues has a significant …
The effect of ageing and osteoarthritis on the mechanical properties of cartilage and bone in the human knee joint
Osteoarthritis is traditionally associated with cartilage degeneration although is now widely
accepted as a whole-joint disease affecting the entire osteochondral unit; however site …
accepted as a whole-joint disease affecting the entire osteochondral unit; however site …
Classification of four distinct osteoarthritis subtypes with a knee joint tissue transcriptome atlas
The limited molecular classifications and disease signatures of osteoarthritis (OA) impede
the development of prediagnosis and targeted therapeutics for OA patients. To classify and …
the development of prediagnosis and targeted therapeutics for OA patients. To classify and …
Molecular taxonomy of osteoarthritis for patient stratification, disease management and drug development: biochemical markers associated with emerging clinical …
A Mobasheri, WE van Spil, E Budd… - Current opinion in …, 2019 - journals.lww.com
In this review, we have focused on the molecular biomarkers of four distinct osteoarthritis
subtypes including inflammatory, subchondral bone remodelling, metabolic syndrome and …
subtypes including inflammatory, subchondral bone remodelling, metabolic syndrome and …