Objectives This study aimed to characterize subchondral bone damages of knee
osteoarthritis (OA) patients in presence of the comorbidities, ie, hypertension and type 2 …

Biological therapy is a thriving area of research and development, and is well established for
chronic forms of rheumatoid arthritis (RA) and ankylosing spondylitis (AS). However, there is …

Osteoarthritis (OA) is a common chronic degenerative joint disease in clinical practice with a
high prevalence, especially in the elderly. Traditional Chinese Medicine (TCM) believes that …

Osteoarthritis (OA) is a common debilitating disease affecting articular joints for which no
effective disease-modifying early diagnosis or medical therapy tools are currently available …

Background Clusterin (CLU; also known as apolipoprotein J) is an ATP-independent
holdase chaperone that prevents proteotoxicity as a consequence of protein aggregation. It …

Objective Viscoelastic properties of articular cartilage have been characterised at
physiological frequencies. However, studies investigating the interaction between cartilage …

Hypothesis The crystallization of calcium phosphate (CaP) is a ubiquitous process that
occurs in several mineralized tissues and involves a variety of biochemical and chemical …

Understanding how structural and functional alterations of individual tissues impact on
whole-joint function is challenging, particularly in humans where direct invasive …

Objective Osteophyte formation in osteoarthritis (OA) is mediated by increased osteoblast
activity, which is-in turn-regulated by the Wnt signaling pathway. Obesity is regarded a risk …

Osteoarthritis (OA) and cardiovascular diseases (CVD) share many similar features,
including similar risk factors and molecular mechanisms. A great number of cardiovascular …