As the most common form of arthritis, osteoarthritis (OA) has become a major cause of
severe joint pain, physical disability, and quality of life impairment in the affected population …

Objective Mechanical stress plays an important role in cartilage degradation and
subchondral bone remodeling in osteoarthritis (OA). The remodeling of the subchondral …

Background Despite it being known that subchondral bone affects the viscoelasticity of
cartilage, there has been little research into the mechanical properties of osteochondral …

Increased subchondral trabecular bone turnover due to imbalanced bone-resorbing and
bone-forming activities is a hallmark of osteoarthritis (OA). Wnt5a/Ror2 signaling, which can …

Objective To give an overview of the literature on the role of small leucine-rich proteoglycans
(SLRPs) in osteoarthritis (OA) pathogenesis. Method A literature search was performed and …

The repair of osteochondral defects remains challenging, given the complexity of native
osteochondral tissue and the limited self-repair capacity of cartilage. Osteochondral tissue …

Glucocorticoids (GCs) are known to have a strong impact on the immune system,
metabolism, and bone homeostasis. While these functions have been long investigated …

Objective Curcumin monoglucuronide (TBP1901) is highly water soluble and can convert to
free form curcumin, which has pharmacological effects, on intravenous administration. This …

Objective The vascularization of subchondral bone plays a significant role in the progression
of knee osteoarthritis (OA). Treatment with platelet-rich plasma (PRP) has positive effects on …

Background Subchondral bone is commonly affected in cases of giant cell tumour (GCT) of
the proximal tibia. Numerous studies have stated that retaining a sufficient subchondral …