Pathophysiological functions of the lncRNA TUG1

C Guo, Y Qi, J Qu, L Gai, Y Shi… - Current pharmaceutical …, 2020 - ingentaconnect.com
Background: Long non-coding RNAs (lncRNAs) with little or no coding capacity are
associated with a plethora of cellular functions, participating in various biological processes …

Beyond the genome: lncRNAs as regulators of the PI3K/AKT pathway in lung cancer

WH Almalki - Pathology-Research and Practice, 2023 - Elsevier
Lung cancer is a prevalent and devastating disease, representing a significant global health
burden. Despite advancements in therapeutic strategies, the molecular mechanisms …

lncRNA TUG1 modulates proliferation, apoptosis, invasion, and angiogenesis via targeting miR-29b in trophoblast cells

Q Li, J Zhang, DM Su, LN Guan, WH Mu, M Yu, X Ma… - Human genomics, 2019 - Springer
Background Pre-eclampsia (PE) is regarded as the leading cause of maternal and neonatal
morbidity and mortality. Nevertheless, the potential mechanism for the regulation of …

Extracellular vesicles from human umbilical cord mesenchymal stem cells reduce lipopolysaccharide-induced spinal cord injury neuronal apoptosis by mediating miR …

X Xiao, W Li, Z Xu, Z Sun, H Ye, Y Wu… - Connective Tissue …, 2022 - Taylor & Francis
Objective This study investigated the molecular mechanism of whether hUC-MSCs-EVs
repressed PTEN expression and activated the PI3K/AKT pathway through miR-29b-3p, thus …

The value of serum microRNA expression signature in predicting refractoriness to bortezomib-based therapy in multiple myeloma patients

P Robak, I Dróżdż, D Jarych, D Mikulski, E Węgłowska… - Cancers, 2020 - mdpi.com
Simple Summary The proteasome inhibitor bortezomib is currently commonly used for the
treatment of multiple myeloma (MM). MicroRNAs (miRNAs) are small non-coding RNAs that …

miR‑29b‑3p inhibits 22Rv1 prostate cancer cell proliferation through the YWHAE/BCL‑2 regulatory axis

J Zhao, X Ma, H Xu - Oncology letters, 2022 - spandidos-publications.com
Prostate cancer (PCa) is one of the most common malignant tumours in the world and
seriously affects health of men. Studies have shown that microRNA (miR)‑29b‑3p and …

Anticancer potential of TUG1 knockdown in cisplatin-resistant osteosarcoma through inhibition of MET/Akt signalling

Q Zhou, T Hu, Y Xu - Journal of drug targeting, 2020 - Taylor & Francis
Abstract Development of cisplatin (DDP)-resistance is a major challenge that largely limits
the efficacy of chemotherapy for osteosarcoma. LncRNA Taurine up-regulated gene 1 …

Downregulation of miR‐29b‐3p aggravates podocyte injury by targeting HDAC4 in LPS‐induced acute kidney injury

ZL Ha, ZY Yu - The Kaohsiung Journal of Medical Sciences, 2021 - Wiley Online Library
Sepsis is a severe organ dysfunction disease, usually accompanied by acute kidney injury
(AKI). miR‐29b‐3p was inhibited in sepsis‐induced AKI, while its role in AKI was unclear …

Knockdown of lncRNA SNHG16 suppresses multiple myeloma cell proliferation by sponging miR-342-3p

X Yang, H Huang, X Wang, H Liu, H Liu, Z Lin - Cancer cell international, 2020 - Springer
Background Aberrant expression of long non-coding RNAs (lncRNAs) is closely associated
with development and prognosis of human cancers. LncRNA SNHG16 is reportedly involved …

Methylation of the miR‑29b‑3p promoter contributes to angiogenesis, invasion, and migration in pancreatic cancer

L Wang, N Mu, N Qu - Oncology Reports, 2021 - spandidos-publications.com
The aim of the present study was to investigate the effects of microRNA (miR)‑29b‑3p gene
promoter methylation on angiogenesis, invasion, and migration in human pancreatic cancer …