Despite the exceptional progress in breast cancer pathogenesis, prognosis, diagnosis, and
treatment strategies, it remains a prominent cause of female mortality worldwide …

Ferroptosis is a new type of oxidative regulated cell death (RCD) driven by iron-dependent
lipid peroxidation. As major sites of iron utilization and master regulators of oxidative …

The majority of therapies that target individual proteins rely on specific activity-modulating
interactions with the target protein—for example, enzyme inhibition or ligand blocking …

Ferroptosis is recognized as a new form of regulated cell death which is initiated by severe
lipid peroxidation relying on reactive oxygen species (ROS) generation and iron overload …

Intracellular organelles are subsystems within a cell, whose activity and chemical
composition reflect the metabolic state of live cells. Alterations in cellular homeostasis …

Targeted protein degradation (TPD) provides unprecedented opportunities for drug
discovery. While the proteolysis-targeting chimera (PROTAC) technology has already …

Circulating tumor cells (CTC) are shed by cancer into the bloodstream, where a viable
subset overcomes oxidative stress to initiate metastasis. We show that single CTCs from …

Polypeptides have attracted considerable attention in recent decades due to their inherent
biodegradability and tunable cytocompatibility. Macromolecular design in conjunction with …

Engineering protein and peptide-based materials for drug delivery applications has gained
momentum due to their biochemical and biophysical properties over synthetic materials …

Iron is an essential trace element for the human body, and its deficiency or excess can
induce a variety of biological processes. Plenty of evidences have shown that iron …