This international guideline proposes improving clozapine package inserts worldwide by
using ancestry-based dosing and titration. Adverse drug reaction (ADR) databases suggest …

Antipsychotic drugs differ in their propensity to cause extrapyramidal side-effects (EPS), but
their dose-effects are unclear. Therefore, we conducted a systematic review and dose …

Objectives: To provide advice and guidance regarding the management of mood disorders,
derived from scientific evidence and supplemented by expert clinical consensus to formulate …

The British Association for Psychopharmacology developed an evidence-based consensus
guideline on the management of catatonia. A group of international experts from a wide …

Atypical antipsychotics (AAPs) are commonly prescribed medications to treat schizophrenia,
bipolar disorders and other psychotic disorders. However, they might cause metabolic …

The American Psychiatric Association Practice Guideline for the Treatment of Patients With
Schizophrenia seeks to reduce these substantial psychosocial and public health …

Importance Precise estimation of the drug metabolism capacity for individual patients is
crucial for adequate dose personalization. Objective To quantify the difference in the …

Abstract Treatment-resistant schizophrenia (TRS) will affect about one in three patients with
schizophrenia. Clozapine is the only treatment approved for TRS, and patients should be …

In order to assess the significance of drug/substance levels measured in intensive care
medicine and clinical and forensic toxicology as well as for therapeutic drug monitoring, it is …

Tandem mass spectrometry–especially in combination with liquid chromatography (LC–
MS/MS)–is applied in a multitude of important diagnostic niches of laboratory medicine. It is …