[HTML][HTML] Role of pyroptosis in cardiovascular diseases and its therapeutic implications

C Zeng, R Wang, H Tan - International journal of biological …, 2019 - ncbi.nlm.nih.gov
Pyroptotic cell death or pyroptosis is characterized by caspase-1-dependent formation of
plasma membrane pores, leading to the release of pro-inflammatory cytokines and cell lysis …

Pyroptosis: a new regulating mechanism in cardiovascular disease

N Ji, Z Qi, Y Wang, X Yang, Z Yan, M Li… - Journal of …, 2021 - Taylor & Francis
Pyroptosis is a kind of pro-inflammatory cell death. Compared with autophagy and
apoptosis, pyroptosis has unique characteristics in morphology and mechanism …

Inflammasome Signaling in Atrial Fibrillation: JACC State-of-the-Art Review

A Ajoolabady, S Nattel, GYH Lip, J Ren - Journal of the American College …, 2022 - jacc.org
As the most prevalent form of arrhythmia, atrial fibrillation (AF) increases the risk of heart
failure, thromboembolism, and stroke, contributing to the raising mortality and morbidity in …

Molecular mechanisms of cardiomyocyte death in drug-induced cardiotoxicity

W Ma, S Wei, B Zhang, W Li - Frontiers in Cell and Developmental …, 2020 - frontiersin.org
Homeostatic regulation of cardiomyocytes plays a crucial role in maintaining the normal
physiological activity of cardiac tissue. Severe cardiotoxicity results in cardiac diseases …

Electroimmunology and cardiac arrhythmia

J Grune, M Yamazoe, M Nahrendorf - Nature reviews cardiology, 2021 - nature.com
Conduction disorders and arrhythmias remain difficult to treat and are increasingly prevalent
owing to the increasing age and body mass of the general population, because both are risk …

Evidence for inflammation as a driver of atrial fibrillation

X Zhou, SC Dudley Jr - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
Atrial fibrillation (AF) is one of the most common types of arrhythmias and increases
cardiovascular morbidity and mortality. Current therapeutic approaches to AF that focus on …

Implications of inflammation and fibrosis in atrial fibrillation pathophysiology

M Harada, S Nattel - Cardiac electrophysiology clinics, 2021 - cardiacep.theclinics.com
Inflammation has been implicated in the pathophysiology of atrial fibrillation (AF) and
mediates various pathologic processes such as oxidative stress and apoptosis. Atrial fibrosis …

Inflammasomes and proteostasis novel molecular mechanisms associated with atrial fibrillation

N Li, BJJM Brundel - Circulation research, 2020 - Am Heart Assoc
Atrial fibrillation (AF), the most common progressive and age-related cardiac arrhythmia,
affects millions of people worldwide. AF is associated with common risk factors, including …

Innate immune receptors, key actors in cardiovascular diseases

RI Jaén, A Val-Blasco, P Prieto, M Gil-Fernández… - Basic to Translational …, 2020 - jacc.org
Cardiovascular diseases (CVDs) are the leading cause of death in the industrialized world.
Most CVDs are associated with increased inflammation that arises mainly from innate …

Atrial fibrosis as a dominant factor for the development of atrial fibrillation: facts and gaps

A Xintarakou, S Tzeis, S Psarras, D Asvestas… - EP …, 2020 - academic.oup.com
Atrial fibrillation (AF), the most commonly diagnosed arrhythmia, affects a notable
percentage of the population and constitutes a major risk factor for thromboembolic events …