Background The proliferation of inhaler devices has resulted in a confusing number of
choices for clinicians who are selecting a delivery device for aerosol therapy. There are …

Background In acute asthma inhaled beta₂‐agonists are often administered by nebuliser to
relieve bronchospasm, but some have argued that metered‐dose inhalers with a holding …

Objectives: To provide physicians with current guidelines for the diagnosis and optimal
management of asthma in children and adults, including pregnant women and the elderly, in …

Acute severe asthma remains a major economic and health burden. The natural history of
acute decompensations is one of resolution and only about 0.4% of patients succumb …

Of the three classes of bronchodilators (β2-adrenergic–receptor agonists, methylxanthines,
and anticholinergic agents), the β2-adrenergic–receptor agonists produce the greatest …

Objective: To compare the effect of bronchodilator delivery by use of a metered-dose inhaler
(MDI) or wet nebulizer on objective measurements of acute airflow obstruction in adult …

Spacer devices are attachments to the mouthpieces of pressurised metered dose inhalers
(pMDIs), and range from tube spacers with a volume of< 50mL to holding chambers with a …

Objective: In children with mild acute asthma, to compare treatment with a single dose of
albuterol delivered by a metered dose inhaler (MDI) with a spacer in either a weight …

Add-on devices for pressurised metered dose inhalers (MDIs) improve" targeting" of drug to
the lungs and can correct for hand–breath dyscoordination. Measurements of drug delivery …

OBJECTIVE: To develop a set of comprehensive, standardized evidence-based guidelines
for the assessment and treatment of acute asthma in adults in the emergency setting …