[HTML][HTML] Going circular: history, present, and future of circRNAs in cancer
To date, thousands of highly abundant and conserved single-stranded RNA molecules
shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional …
shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional …
[HTML][HTML] Circular RNA and its roles in the occurrence, development, diagnosis of cancer
Y Zhang, X Zhang, Y Xu, S Fang, Y Ji, L Lu… - Frontiers in …, 2022 - frontiersin.org
Circular RNAs (circRNAs) are non-coding single-stranded covalently closed circular RNA,
mainly produced by reverse splicing of exons of precursor mRNAs (pre-mRNAs). The …
mainly produced by reverse splicing of exons of precursor mRNAs (pre-mRNAs). The …
[HTML][HTML] CircZBTB46 Protects Acute Myeloid Leukemia Cells from Ferroptotic Cell Death by Upregulating SCD
F Long, Z Lin, Q Long, Z Lu, K Zhu, M Zhao, M Yang - Cancers, 2023 - mdpi.com
Simple Summary It is urgent to identify new biomarkers for diagnosis, prognostication, and
therapeutic targets of acute myeloid leukemia (AML) so as to develop more effective …
therapeutic targets of acute myeloid leukemia (AML) so as to develop more effective …
Complete miRNA-15/16 loss in mice promotes hematopoietic progenitor expansion and a myeloid-biased hyperproliferative state
A Ng, F Lovat, AJ Shih, Y Ma… - Proceedings of the …, 2023 - National Acad Sciences
Dysregulated apoptosis and proliferation are fundamental properties of cancer, and
microRNAs (miRNA) are critical regulators of these processes. Loss of miR-15a/16-1 at …
microRNAs (miRNA) are critical regulators of these processes. Loss of miR-15a/16-1 at …
[HTML][HTML] The novel β-TrCP protein isoform hidden in circular RNA confers trastuzumab resistance in HER2-positive breast cancer
S Wang, Y Wang, Q Li, X Li, X Feng, K Zeng - Redox Biology, 2023 - Elsevier
Trastuzumab notably improves the outcome of human epidermal growth factor receptor 2
(HER2)-positive breast cancer patients, however, resistance to trastuzumab remains a major …
(HER2)-positive breast cancer patients, however, resistance to trastuzumab remains a major …
[HTML][HTML] METTL3-mediated m6A modification of circRNF220 modulates miR-330-5p/survivin axis to promote osteosarcoma progression
F Liu, W Li, Z Jin, J Ye - Journal of Cancer Research and Clinical …, 2023 - Springer
Abstract Background Circular RNAs (circRNAs) play a crucial role in regulating various
physiological processes. However, the precise regulatory mechanisms of circRNF220s in …
physiological processes. However, the precise regulatory mechanisms of circRNF220s in …
[HTML][HTML] Circular RNAs: pivotal role in the leukemogenesis and novel indicators for the diagnosis and prognosis of acute myeloid leukemia
A Rahmati, A Mafi, F Soleymani… - Frontiers in …, 2023 - frontiersin.org
Acute myeloid leukemia (AML) is an aggressive hematological malignancy and affected
patients have poor overall survival (OS) rates. Circular RNAs (circRNAs) are a novel class of …
patients have poor overall survival (OS) rates. Circular RNAs (circRNAs) are a novel class of …
[HTML][HTML] circCRKL, a circRNA derived from CRKL, regulates BCR-ABL via sponging miR-877-5p to promote chronic myeloid leukemia cell proliferation
J Wang, Y Liang, Y Qin, G Jiang, Y Peng… - Journal of Translational …, 2022 - Springer
Abstract Background The BCR-ABL fusion protein is the key factor that results in the
occurrence of chronic myeloid leukemia (CML). Imatinib (IM) is a targeted inhibitor of BCR …
occurrence of chronic myeloid leukemia (CML). Imatinib (IM) is a targeted inhibitor of BCR …
[HTML][HTML] Circular RNAs activity in the leukemic bone marrow microenvironment
F Liccardo, A Iaiza, M Śniegocka, S Masciarelli, F Fazi - Non-coding RNA, 2022 - mdpi.com
Acute myeloid leukemia (AML) is a hematological malignancy originating from defective
hematopoietic stem cells in the bone marrow. In spite of the recent approval of several …
hematopoietic stem cells in the bone marrow. In spite of the recent approval of several …
[HTML][HTML] An update on circular RNA in pediatric cancers
A Galardi, M Colletti, A Palma, A Di Giannatale - Biomedicines, 2022 - mdpi.com
Circular RNAs (circRNAs) are a class of single-stranded closed noncoding RNA molecules
which are formed as a result of reverse splicing of mRNAs. Despite their relative abundance …
which are formed as a result of reverse splicing of mRNAs. Despite their relative abundance …