Mammals have two specialized vascular circulatory systems: the blood vasculature and the
lymphatic vasculature. The lymphatic vasculature is a unidirectional conduit that returns …

The lymphatic vasculature has an essential role in maintaining normal fluid balance in
tissues and modulating the inflammatory response to injury or pathogens. Disruption of …

The lineage and developmental trajectory of a cell are key determinants of cellular identity.
In the vascular system, endothelial cells (ECs) of blood and lymphatic vessels differentiate …

Lymphatic vessels, comprising the secondary circulatory system in human body, play a
multifaceted role in maintaining homeostasis among various tissues and organs. They are …

Background: Certain nonmammalian species such as zebrafish have an elevated capacity
for innate heart regeneration. Understanding how heart regeneration occurs in these …

Background: The adherens protein VE-cadherin (vascular endothelial cadherin) has diverse
roles in organ-specific lymphatic vessels. However, its physiological role in cardiac …

Background Promoting cardiac lymphangiogenesis exerts beneficial effects for the heart.
Exercise can induce physiological cardiac growth with cardiomyocyte hypertrophy and …

The lymphatic system plays important roles in physiological and pathological conditions.
During cancer progression in particular, lymphangiogenesis can exert both positive and …

Recent advances in our understanding of the lymphatic system, its function, development,
and role in pathophysiology have changed our views on its importance. Historically thought …

Our understanding of the function and development of the lymphatic system is expanding
rapidly due to the identification of specific molecular markers and the availability of novel …