Receptor tyrosine kinases (RTKs) and their cellular signaling pathways play important roles
in normal development and homeostasis. Aberrations in their activation or signaling leads to …

Epidermal growth factor (EGF) is a single polypeptide of 53 amino acid residues which is
involved in the regulation of cell proliferation. Egf exerts its effects in the target cells by …

Protein kinases share a number of highly conserved or invariant amino acid residues in their
catalytic domains, suggesting that these residues are necessary for kinase activity. In …

The epidermal growth factor receptor plays crucial roles throughout the development of
multicellular organisms, and inappropriate activation of the receptor is associated with …

Within a multi-celled organism, regulation and organization require that biological signals be
transmitted from one cell to another, across cell membranes. Such is the case with growth …

The c-kit receptor tyrosine kinase (KIT) is activated upon ligand binding, thereby leading to a
variety of signaling events that play a fundamental role in hematopoiesis. In addition to …

Mutations at the mouse W/c-kit locus lead to intrinsic defects in stem cells of the melanocytic,
hematopoietic, and germ cell lineages. W alleles vary in the overall severity of phenotype …

A major process through which environmental information is transmitted into cells is via
activation of protein tyrosine kinases. Receptor tyrosine kinases contain extracellular ligand …

The type-III deletion variant of the epidermal growth factor receptor (EGFRvIII) is frequently
found in glioblastomas and other malignant human tumours. Although EGFRvIII confers …

The mutant c-erbB-2 protein with Glu instead of Val-659 exhibited transforming activity in
NIH 3T3 cells. This protein showed enhanced tyrosine kinase activity in vitro and enhanced …