Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease–novel insights into cellular communication circuits

M Peiseler, R Schwabe, J Hampe, P Kubes… - Journal of …, 2022 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease and is
emerging as the leading cause of cirrhosis, liver transplantation and hepatocellular …

[HTML][HTML] The bidirectional immune crosstalk in metabolic dysfunction-associated steatotic liver disease

K Sawada, H Chung, S Softic, ME Moreno-Fernandez… - Cell Metabolism, 2023 - cell.com
Metabolic dysfunction-associated steatotic liver disease (MASLD) is an unabated risk factor
for end-stage liver diseases with no available therapies. Dysregulated immune responses …

[HTML][HTML] Hepatic stellate cell-immune interactions in NASH

JK Carter, SL Friedman - Frontiers in Endocrinology, 2022 - frontiersin.org
Nonalcoholic fatty liver disease (NAFLD) is the dominant cause of liver disease worldwide.
Nonalcoholic steatohepatitis (NASH), a more aggressive presentation of NAFLD, is …

[HTML][HTML] Epidemiologic, genetic, pathogenic, metabolic, epigenetic aspects involved in NASH-HCC: current therapeutic strategies

J Gutiérrez-Cuevas, S Lucano-Landeros… - Cancers, 2022 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is an aggressive human cancer and is
caused as consequences of chronic liver diseases. Although HCC is more common in …

[HTML][HTML] Non-alcoholic fatty liver disease: Immunological mechanisms and current treatments

L Petagine, MG Zariwala, VB Patel - World Journal of …, 2023 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) causes significant global disease burden and is a
leading cause of mortality. NAFLD induces a myriad of aberrant changes in hepatocytes at …

[HTML][HTML] The role of complement in nonalcoholic fatty liver disease

Z Guo, X Fan, J Yao, S Tomlinson, G Yuan… - Frontiers in …, 2022 - frontiersin.org
Nonalcoholic fatty liver disease (NAFLD) has become a leading cause of chronic liver
diseases globally. NAFLD includes a range of hepatic manifestations, starting with liver …

[HTML][HTML] Bidirectional association between psoriasis and nonalcoholic fatty liver disease: real-world evidence from two longitudinal cohort studies

SY Gau, KH Huang, CH Lee, YH Kuan… - Frontiers in …, 2022 - frontiersin.org
Background Association between nonalcoholic fatty liver disease (NAFLD) and future
psoriasis has not yet been confirmed, although the two diseases partially share a common …

[HTML][HTML] MAIT cells in liver inflammation and fibrosis

H Mehta, MJ Lett, P Klenerman… - Seminars in …, 2022 - Springer
Mucosal-associated invariant T cells or MAIT cells are an abundant cell type in humans and
especially so in the liver. MAIT cells are a subset of T lymphocytes that sit at a bridge …

[HTML][HTML] Changes in m6A in steatotic liver disease

BJ Petri, MC Cave, CM Klinge - Genes, 2023 - mdpi.com
Fatty liver disease is one of the major causes of morbidity and mortality worldwide. Fatty liver
includes non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis …

HILPDA promotes NASH-driven HCC development by restraining intracellular fatty acid flux in hypoxia

D Povero, Y Chen, SM Johnson, CE McMahon… - Journal of …, 2023 - Elsevier
Background & Aims The prevalence of non-alcoholic steatohepatitis (NASH)-driven
hepatocellular carcinoma (HCC) is rising rapidly, yet its underlying mechanisms remain …