Ceramide has been shown to be critically involved in many aspects of cellular responses to
receptor-dependent and-independent stimuli. For instance, ceramide was demonstrated to …

Metabolic syndrome X and type 2 diabetes share many metabolic and morphological
similarities with Cushing's syndrome, a rare disorder caused by systemic glucocorticoid …

Sphingolipids are a class of membrane lipids that serve as vital structural and signaling
bioactive molecules in organisms ranging from yeast to animals. Recent studies have …

Distinct domains in the cell membrane, termed rafts, emerge as central for the infection of
mammalian cells by many pathogens. Rafts consist of sphingolipids and cholesterol that …

Acid sphingomyelinase (ASM) plays an important role in normal membrane turnover through
the hydrolysis of sphingomyelin, and is one of the key enzymes responsible for the …

Sphingolipid metabolites, ceramide, sphingosine, and sphingosine 1-phosphate, have
emerged as a new class of lipid biomodulators of various cell functions. These metabolites …

Sphingolipids such as sphingosine-1-phosphate (S1P), ceramide, or sphingomyelin are
essential constituents of plasma membranes and regulate many (patho) physiological …

We have previously shown that activation of the acid sphingomyelinase (ASM), the release
of ceramide and the formation of ceramide-enriched membrane domains are central for the …

The vascular endothelium from individual organs is functionally specialized, and it displays
a unique set of accessible molecular targets. These serve as endothelial cell receptors to …

Ceramide has been shown to be critically involved in many forms of apoptosis including
death triggered by receptors, eg CD95 or the tumor necrosis factor receptor, during …