Heart failure is a leading cause of mortality and hospitalization worldwide. Cardiac fibrosis,
resulting from the excessive deposition of collagen fibers, is a common feature across the …

Simple Summary Inflammation is like the proverbial double-edged sword. Controlled short-
term inflammation could be a protective response while uncontrolled inflammation sustains …

Acute myocardial infarction (MI) occurs when blood flow to the myocardium is restricted,
leading to cardiac damage and massive loss of viable cardiomyocytes. Timely restoration of …

Despite the significant decline in mortality, cardiovascular diseases are still the leading
cause of death worldwide. Among them, myocardial infarction (MI) seems to be the most …

Perception of the role of the aldosterone/mineralocorticoid receptor (MR) ensemble has
been extended from a previously renal epithelial-centered focus on sodium and volume …

Drug-induced cardiotoxicity (DICT) is a major concern in drug development, accounting for
10–14% of postmarket withdrawals. In this study, we explored the capabilities of chemical …

There is a lack of direct evidence regarding gut microbiota dysbiosis and changes in short-
chain fatty acids (SCFAs) in heart failure (HF) patients. We sought to assess any association …

Introduction Leukocyte infiltration is an early event during cardiac remodeling frequently
leading to heart failure (HF). Integrins mediate leukocyte infiltration during inflammation …

Cardiac abnormalities were identified early in the epidemic of AIDS, predating the isolation
and characterization of the etiologic agent, HIV. Several decades later, the causation and …

Cardiac fibrosis is one of the main causes of heart failure, significantly contributing to
mortality. The discovery and development of effective therapies able to heal fibrotic …