[HTML][HTML] Senescence-associated secretory phenotype of cardiovascular system cells and inflammaging: perspectives of peptide regulation

V Khavinson, N Linkova, A Dyatlova, R Kantemirova… - Cells, 2022 - mdpi.com
A senescence-associated secretory phenotype (SASP) and a mild inflammatory response
characteristic of senescent cells (inflammaging) form the conditions for the development of …

KATP channels are regulators of programmed cell death and targets for the creation of novel drugs against ischemia/reperfusion cardiac injury

LN Maslov, SV Popov, NV Naryzhnaya… - Fundamental & …, 2023 - Wiley Online Library
Background The use of percutaneous coronary intervention (PCI) in patients with ST‐
segment elevation myocardial infarction (STEMI) is associated with a mortality rate of 5 …

Mechanism of METTL3-Mediated m6A Modification in Cardiomyocyte Pyroptosis and Myocardial Ischemia–Reperfusion Injury

X Wang, Y Li, J Li, S Li, F Wang - Cardiovascular drugs and therapy, 2023 - Springer
Objective Myocardial ischemia/reperfusion (MI/R) injury is a complicated pathophysiological
process associated with cardiomyocyte pyroptosis. Methyltransferase-like protein 3 …

[HTML][HTML] PPAR alpha activation by clofibrate alleviates ischemia/reperfusion injury in metabolic syndrome rats by decreasing cardiac inflammation and remodeling and …

M Sánchez-Aguilar, L Ibarra-Lara… - International Journal of …, 2023 - mdpi.com
Metabolic syndrome (MetS) is a cluster of factors that increase the risk of developing
diabetes, stroke, and heart failure. The pathophysiology of injury by ischemia/reperfusion …

[HTML][HTML] The Infarct-Reducing Effect of the δ2 Opioid Receptor Agonist Deltorphin II: The Molecular Mechanism

SV Popov, AV Mukhomedzyanov, LN Maslov… - Membranes, 2023 - mdpi.com
The search for novel drugs for the treatment of acute myocardial infarction and reperfusion
injury of the heart is an urgent aim of modern pharmacology. Opioid peptides could be such …

[HTML][HTML] Functional Regulation of KATP Channels and Mutant Insight Into Clinical Therapeutic Strategies in Cardiovascular Diseases

Z Wang, W Bian, Y Yan, DM Zhang - Frontiers in Pharmacology, 2022 - frontiersin.org
ATP-sensitive potassium channels (KATP channels) play pivotal roles in excitable cells and
link cellular metabolism with membrane excitability. The action potential converts electricity …

[HTML][HTML] The effect of an adaptation to hypoxia on cardiac tolerance to ischemia/reperfusion

NV Naryzhnaya, LN Maslov, IA Derkachev… - Journal of Biomedical …, 2023 - ncbi.nlm.nih.gov
The acute myocardial infarction (AMI) and sudden cardiac death (SCD), both associated
with acute cardiac ischemia, are one of the leading causes of adult death in economically …

Myrtenol improves brain damage and promotes angiogenesis in rats with cerebral infarction by activating the ERK1/2 signalling pathway

S Huang, Z Tan, J Cai, Z Wang, Y Tian - Pharmaceutical Biology, 2021 - Taylor & Francis
Context Cerebral ischaemia/reperfusion (I/R) injury has a high disability and fatality
worldwide. Myrtenol has protective effects on myocardial I/R injury through antioxidant and …

A comprehensive overview of organ inflammatory responses: genesis, possible mechanisms, and mediators of inflammation

SA Antar, AM Mahmoud, W Abdo, C Gad… - Pharmaceutical …, 2023 - e-space.mmu.ac.uk
An immune system response known as inflammation can be carried on by a variety of things,
such as infections, damaged cells, and noxious substances. These factors may cause acute …

Mitochondrial KATP channel-mediated autophagy contributes to angiotensin II-induced vascular dysfunction in mice

XM Yin, YY Song, WY Jiang, HT Zhang… - Nutrition, Metabolism …, 2024 - Elsevier
Background and aim The present study aimed to investigate whether the mitochondrial K
ATP channel contributes to angiotensin II (Ang II)-induced vascular dysfunction, the …