We carried out a genome-wide association study (GWAS) of congenital heart disease
(CHD). Our discovery cohort comprised 1,995 CHD cases and 5,159 controls and included …

The conduction system of the heart initiates and coordi-nates the electric signal that causes
the rhythmic and synchronized contractions of the atria and ventricles. In higher vertebrates …

Gap junctions are specialized cell–cell junctions that directly link the cytoplasm of
neighboring cells. They mediate the direct transfer of metabolites and ions from one cell to …

The cardiac conduction system is a specialized tract of myocardial cells responsible for
maintaining normal cardiac rhythm. Given its critical role in coordinating cardiac …

Ventricular preexcitation, a feature of Wolff-Parkinson-White syndrome, is caused by
accessory myocardial pathways that bypass the annulus fibrosus. This condition increases …

The creation of a functional 3D bioprinted human heart remains challenging, largely due to
the lack of some crucial cardiac cell types, including the atrioventricular canal (AVC) …

The generation and propagation of the cardiac impulse is the central function of the cardiac
conduction system (CCS). Impulse initiation occurs in nodal tissues that have high levels of …

Abstract T-box 2 (TBX2) is a transcription factor involved in mammary development and is
known to be overexpressed in a subset of aggressive breast cancers. TBX2 has previously …

The T‐box transcription factor Tbx3 plays multiple roles in normal development and disease.
In order to function in different tissues and on different target genes, Tbx3 binds transcription …

The cardiac conduction system initiates and propagates each heartbeat. Specialized
conducting cells are a well-conserved phenomenon across vertebrate evolution, although …