Formation of the mammalian secondary palate is a highly regulated and complex process.
Impairment of the underlying cellular and molecular programs often results in cleft palate, a …

Abstract T‐box (Tbx) 3, a known transcriptional repressor, is a member of a family of
transcription factors, which contain a highly homologous DNA binding domain known as the …

Vascular calcification increases morbidity and mortality in patients with cardiovascular and
renal diseases. Previously, we reported that histone deacetylase 1 prevents vascular …

The vertebrate heart is a muscular pump that contracts in a rhythmic fashion to propel the
blood through the body. During evolution, the morphologically complex four-chambered …

The closely related T-box transcription factors TBX2 and TBX3 are frequently overexpressed
in melanoma and various types of human cancers, in particular, breast cancer. The …

The antiproliferative activity of transforming growth factor-β (TGF-β) is essential for
maintaining normal tissue homeostasis and is lost in many types of tumors. Gene responses …

Tbx2 is a member of a large family of transcription factors defined by homology to the T-box
DNA-binding domain. Tbx2 plays a key role in embryonic development, and in cancer …

Background Msx originated early in animal evolution and is implicated in human genetic
disorders. To reconstruct the functional evolution of Msx and inform the study of human …

Tbx3, a T-box transcription factor, regulates key steps in development of the heart and other
organ systems. Here, we identify Sox4 as an interacting partner of Tbx3. Pull-down and …

Atrioventricular conduction cardiomyocytes (AVCCs) regulate the rate and rhythm of heart
contractions. Dysfunction due to aging or disease can cause atrioventricular (AV) block …