Amyotrophic lateral sclerosis is characterised by the progressive loss of motor neurons in
the brain and spinal cord. This neurodegenerative syndrome shares pathobiological …

Background Neuroimaging studies help us better understand the pathophysiology and
symptoms of Parkinson's disease (PD). In several of these studies, diffusion tensor imaging …

In the past two decades, structural and functional neuroimaging findings have greatly
modified longstanding notions regarding the pathophysiology of amyotrophic lateral …

Motor neuron disease can be viewed as an umbrella term describing a heterogeneous
group of conditions, all of which are relentlessly progressive and ultimately fatal. The …

Diffusion-tensor imaging (DTI) is a noninvasive medical imaging tool used to investigate the
structure of white matter. The signal contrast in DTI is generated by differences in the …

Diffusion tensor imaging can identify amyotrophic lateral sclerosis-associated patterns of
brain alterations at the group level. Recently, a neuropathological staging system for …

Objective Damage to the cerebral tissue structural connectivity associated with amyotrophic
lateral sclerosis (ALS), which extends beyond the motor pathways, can be visualised by …

Introduction The use of machine learning (ML) techniques in healthcare encompasses an
emerging concept that envisages vast contributions to the tackling of rare diseases. In this …

The search for diagnostic and prognostic biomarkers for neurodegenerative conditions is of
high importance, since these disorders may present difficulties in differential diagnosis …

Amyotrophic lateral sclerosis (ALS) is now universally recognized as a complex multisystem
disorder with considerable extra-motor involvement. The neuropsychological manifestations …