Deafness: From genetic architecture to gene therapy
Progress in deciphering the genetic architecture of human sensorineural hearing
impairment (SNHI) or loss, and multidisciplinary studies of mouse models, have led to the …
impairment (SNHI) or loss, and multidisciplinary studies of mouse models, have led to the …
[HTML][HTML] Advances in gene therapy hold promise for treating hereditary hearing loss
L Jiang, D Wang, Y He, Y Shu - Molecular Therapy, 2023 - cell.com
Gene therapy focuses on genetic modification to produce therapeutic effects or treat
diseases by repairing or reconstructing genetic material, thus being expected to be the most …
diseases by repairing or reconstructing genetic material, thus being expected to be the most …
[HTML][HTML] Inner ear gene therapies take off: current promises and future challenges
S Delmaghani, A El-Amraoui - Journal of clinical medicine, 2020 - mdpi.com
Hearing impairment is the most frequent sensory deficit in humans of all age groups, from
children (1/500) to the elderly (more than 50% of the over-75 s). Over 50% of congenital …
children (1/500) to the elderly (more than 50% of the over-75 s). Over 50% of congenital …
The genomics of auditory function and disease
S Taiber, K Gwilliam, R Hertzano… - Annual review of …, 2022 - annualreviews.org
Current estimates suggest that nearly half a billion people worldwide are affected by hearing
loss. Because of the major psychological, social, economic, and health ramifications …
loss. Because of the major psychological, social, economic, and health ramifications …
[HTML][HTML] Advances and challenges in adeno-associated viral inner-ear gene therapy for sensorineural hearing loss
There is growing attention and effort focused on treating the root cause of sensorineural
hearing loss rather than managing associated secondary characteristic features. With recent …
hearing loss rather than managing associated secondary characteristic features. With recent …
Gene therapy restores auditory functions in an adult Vglut3 knockout mouse model
X Zhao, H Liu, H Liu, R Cai, H Wu - Human Gene Therapy, 2022 - liebertpub.com
Adeno-associated virus (AAV)-based gene therapy has been demonstrated to be extremely
effective for treating genetic hearing loss over the past several years. However, successful …
effective for treating genetic hearing loss over the past several years. However, successful …
[HTML][HTML] Vestibular deficits in deafness: Clinical presentation, animal modeling, and treatment solutions
A Maudoux, S Vitry, A El-Amraoui - Frontiers in neurology, 2022 - frontiersin.org
The inner ear is responsible for both hearing and balance. These functions are dependent
on the correct functioning of mechanosensitive hair cells, which convert sound-and motion …
on the correct functioning of mechanosensitive hair cells, which convert sound-and motion …
Advances in cochlear gene therapies
MJ Klimara, RJH Smith - Current opinion in pediatrics, 2023 - journals.lww.com
Gene therapies for hearing loss are expected to enter clinical trials in the immediate future.
To provide referral for appropriate trials and counseling regarding benefits of genetic …
To provide referral for appropriate trials and counseling regarding benefits of genetic …
Advances in genome editing for genetic hearing loss
Abstract According to the World Health Organization, hearing loss affects over 466 million
people worldwide and is the most common human sensory impairment. It is estimated that …
people worldwide and is the most common human sensory impairment. It is estimated that …
Adeno-associated virus gene replacement for recessive inner ear dysfunction: Progress and challenges
Approximately 3 in 1000 children in the US under 4 years of age are affected by hearing
loss. Currently, cochlear implants represent the only line of treatment for patients with severe …
loss. Currently, cochlear implants represent the only line of treatment for patients with severe …