The assembly of a short linear natural cytosine-phosphate-guanine DNA into dendritic structures and its effect on immunostimulatory activity
DNA containing unmethylated CpG dinucleotides, or CpG motifs,(CpG DNA) has been
explored as a therapeutic agent, owing to its potent immunostimulatory activity. A previous …
explored as a therapeutic agent, owing to its potent immunostimulatory activity. A previous …
Oligodeoxynucleotide IMT504: Effects on Central Nervous System Repair Following Demyelination
PA Mathieu, YR Sampertegui, F Elias, AS Silva… - Molecular …, 2024 - Springer
Multiple sclerosis (MS) is an immune-mediated central nervous system (CNS) disease
characterized by demyelination resulting from oligodendrocyte loss and inflammation …
characterized by demyelination resulting from oligodendrocyte loss and inflammation …
Single-stranded oligodeoxynucleotides induce plant defence in Arabidopsis thaliana
L Toum, G Conti, FC Guerriero, VP Conforte… - Annals of …, 2020 - academic.oup.com
Abstract Background and Aims Single-stranded DNA oligodeoxynucleotides (ssODNs) have
been shown to elicit immune responses in mammals. In plants, RNA and genomic DNA can …
been shown to elicit immune responses in mammals. In plants, RNA and genomic DNA can …
Intrathecal administration of an anti‐nociceptive non-CpG oligodeoxynucleotide reduces glial activation and central sensitization
C Leiguarda, A Villarreal, C Potilinski… - Journal of Neuroimmune …, 2021 - Springer
Inflammatory pain associates with spinal glial activation and central sensitization. Systemic
administration of IMT504, a non-CpG oligodeoxynucleotide originally designed as an …
administration of IMT504, a non-CpG oligodeoxynucleotide originally designed as an …
Non-clinical safety studies of IMT504, a unique non-CpG oligonucleotide
R Franco, JM Rodriguez, F Elias… - Nucleic acid …, 2014 - liebertpub.com
IMT504 is a non-CpG 24-mer oligodeoxynucleotide (ODN) with immunomodulatory as well
as tissue repair activity. IMT504 has been previously proven to be effective in animal models …
as tissue repair activity. IMT504 has been previously proven to be effective in animal models …
Oligonucleotide IMT504 improves glucose metabolism and controls immune cell mediators in female diabetic NOD mice
S Bianchi, VC Martinez Allo, M Massimino… - nucleic acid …, 2021 - liebertpub.com
Type 1 diabetes occurs as a consequence of progressive autoimmune destruction of beta
cells. A potential treatment for this disease should address the immune attack on beta cells …
cells. A potential treatment for this disease should address the immune attack on beta cells …
A high dose of IMT504, the PyNTTTTGT prototype immunostimulatory oligonucleotide, does not alter embryonic development in rats
A Hernando-Insúa, JM Rodriguez, F Elías, J Fló… - …, 2010 - liebertpub.com
Synthetic oligodeoxynucleotides (ODNs) are currently being evaluated as vaccine adjuvants
for inducing protective immunity. As maternal vaccination is becoming increasingly common …
for inducing protective immunity. As maternal vaccination is becoming increasingly common …
Addition of the immunostimulatory oligonucleotide IMT504 to a seasonal flu vaccine increases hemagglutinin antibody titers in young adult and elder rats, and …
AD Montaner, A DeNichilo, JM Rodríguez… - nucleic acid …, 2011 - liebertpub.com
Flu vaccines are partially protective in infants and elder people. New adjuvants such as
immunostimulatory oligonucleotides (ODNs) are strong candidates to solve this problem …
immunostimulatory oligonucleotides (ODNs) are strong candidates to solve this problem …
Oligodeoxynucleotide IMT504: lack of effect on immune parameters during islet regeneration in single dose streptozotocin‐induced diabetes
MS Bianchi, V Calvo, NA Chasseing… - Diabetes/metabolism …, 2012 - Wiley Online Library
Background We have shown that oligodeoxynucleotide IMT504 improved blood glucose
and islet beta‐cell content in streptozotocin (STZ)‐induced diabetic rats, inducing early …
and islet beta‐cell content in streptozotocin (STZ)‐induced diabetic rats, inducing early …
Murine J774 macrophages recognize LPS/IFN-g, non-CpG DNA or two-CpG DNA-containing sequences as immunologically distinct
L Crosby, W Casey, K Morgan, H Ni, L Yoon, M Easton… - Nitric Oxide, 2010 - Elsevier
Specific bacterial lipopolysaccharides (LPS), IFN-γ, and unmethylated cytosine or
guanosine-phosphorothioate containing DNAs (CpG) activate host immunity, influencing …
guanosine-phosphorothioate containing DNAs (CpG) activate host immunity, influencing …