Preclinical models of human disease provide powerful tools for therapeutic discovery but
have limitations. This problem is especially apparent in the field of acute kidney injury (AKI) …

In land mammals, a major task of the kidney is to reabsorb water to allow survival in a dry
environment. Water conservation is enhanced by the renal medulla, which concentrates the …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

The paradigm for recovery of the renal tubule from acute tubular necrosis is that surviving
cells from the areas bordering the injury must migrate into the regions of tubular denudation …

Tissue hypoxia has been proposed as an important factor in the pathophysiology of both
chronic kidney disease (CKD) and acute kidney injury (AKI), initiating and propagating a …

Free radicals and inflammatory mediators are involved in transient focal cerebral ischemia
(FCI). Preadministration of N‐acetylcysteine (NAC) has been found to attenuate the cerebral …

Early medullary hypoxic injury from radiocontrast and indomethacin. We evaluated the acute
changes in cortical and outer medullary oxygen tension and the alterations in renal function …

Diagnosis and classification of acute pathology in the kidney are major clinical problems.
Azotemia and oliguria represent not only disease but normal responses of the kidney to …

Work during the past several years has produced new insights into many aspects of the cell
biology of ischemic injury to the tubulointerstitium. The major processes are conveniently …

Acute renal failure (ARF) due to ischemic or toxic renal injury, a clinical syndrome
traditionally referred to as acute tubular necrosis (ATN), is a common disease with a high …