Risk factors and biomarkers of age-related macular degeneration

NG Lambert, H ElShelmani, MK Singh… - Progress in retinal and …, 2016 - Elsevier
A biomarker can be a substance or structure measured in body parts, fluids or products that
can affect or predict disease incidence. As age-related macular degeneration (AMD) is the …

Mechanisms of age-related macular degeneration

J Ambati, BJ Fowler - Neuron, 2012 - cell.com
Age-related macular degeneration (AMD), a progressive condition that is untreatable in up
to 90% of patients, is a leading cause of blindness in the elderly worldwide. The two forms of …

Age‐related macular degeneration: new paradigms for treatment and management of AMD

LF Hernández-Zimbrón… - Oxidative medicine …, 2018 - Wiley Online Library
Age‐related macular degeneration (AMD) is a well‐characterized and extensively studied
disease. It is currently considered the leading cause of visual disability among patients over …

Systemic complement inhibition with eculizumab for geographic atrophy in age-related macular degeneration: the COMPLETE study

Z Yehoshua, CA de Amorim Garcia Filho, RP Nunes… - Ophthalmology, 2014 - Elsevier
Purpose To evaluate the effect of eculizumab, a systemic inhibitor of complement
component (C5), on the growth of geographic atrophy (GA) in patients with age-related …

Early and intermediate age-related macular degeneration: update and clinical review

A García-Layana, F Cabrera-López… - … interventions in aging, 2017 - Taylor & Francis
Age-related macular degeneration (AMD) is the leading cause of irreversible central vision
loss in developed countries. With the aging of population, AMD will become globally an …

Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma

K Zhang, L Zhang, RN Weinreb - Nature reviews Drug discovery, 2012 - nature.com
Blindness affects 60 million people worldwide. The leading causes of irreversible blindness
include age-related macular degeneration, retinal vascular diseases and glaucoma. The …

[HTML][HTML] Oxidative stress, innate immunity, and age-related macular degeneration

PX Shaw, T Stiles, C Douglas, D Ho, W Fan… - AIMS molecular …, 2016 - ncbi.nlm.nih.gov
Age-related macular degeneration (AMD) is a leading cause of vision loss affecting tens of
millions of elderly worldwide. Early AMD is characterized by the appearance of soft drusen …

Harmonizing the classification of age-related macular degeneration in the three-continent AMD consortium

R Klein, SM Meuer, CE Myers… - Ophthalmic …, 2014 - Taylor & Francis
Purpose: To describe methods to harmonize the classification of age-related macular
degeneration (AMD) phenotypes across four population-based cohort studies: the Beaver …

Overview of risk factors for age-related macular degeneration (AMD).

RA Armstrong, M Mousavi - Journal of stem cells, 2015 - search.ebscohost.com
Age related macular degeneration (AMD) is the leading cause of blindness in individuals
older than 65 years of age. It is a multifactorial disorder and identification of risk factors …

Genetic insights into age-related macular degeneration: controversies addressing risk, causality, and therapeutics

MB Gorin - Molecular aspects of medicine, 2012 - Elsevier
Age-related macular degeneration (AMD) is a common condition among the elderly
population that leads to the progressive central vision loss and serious compromise of …