Parents of children with autism spectrum disorders (ASD) try many and varied interventions
and therapies in the hopes of improving their children's outcomes; however, empirical …

Researchers disagree whether placebo effects are clinically important. The controversy is
partly due to conceptual and methodological problems. The objective of this paper is to …

Objective. To compare the efficacy and tolerability of sumatriptan nasal spray (NS; 5 mg, 10
mg, and 20 mg) with placebo for the treatment of acute migraine in adolescents. Methods. A …

Nocebo effects, such as side effects due to negative expectations regarding the pain
treatment, are a concern for health care providers and come with significant costs. This …

Pregabalin has demonstrated efficacy in several forms of neuropathic pain, but its long-term
efficacy in central post-stroke pain (CPSP) is unproven. We evaluated the efficacy and safety …

Surgical procedures are frequently introduced into general practice on the basis of
uncontrolled studies that are less rigorous than those required for the approval of medical …

Although it is now well accepted that attention-based cognitive coping strategies are
effective in altering pain perception and have potentially useful analgesic qualities, there …

Background/objective A Paleolithic diet may improve fatigue and quality of life in progressive
multiple sclerosis (MS) patients, but past research has evaluated the effects of this dietary …

This study evaluated a possible placebo effect by pacemaker implantation. The study design
was a 3-month multicenter, double-blind, randomized cross-over study to compare the …

Recent evidence suggests that the placebo effect is mediated by the dopaminergic reward
mechanisms in the human brain and that it is related to the expectation of clinical benefit. On …