Introduction Obesity is associated with many physiological changes. We review available
evidence regarding five commonly accepted assumptions to a priori predict the impact of …

Introduction: Obesity is associated with many physiological changes. We review available
evidence regarding five commonly accepted assumptions to a priori predict the impact of …

Drug dosing in obese patients continues to be challenging due to a lack of high‐quality
evidence to guide dosing recommendations. We first published guidance for antibiotic …

Guidelines for surgical prophylactic dosing of cefazolin in bariatric surgery vary in terms of
recommended dose. This study aimed to describe the plasma and interstitial fluid (ISF) …

Bacteremia and endocarditis are two clinical syndromes that, for decades, were managed
exclusively with parenteral antimicrobials, irrespective of a given patient's clinical condition …

The objective of this study was to evaluate the steady state pharmacokinetics and
pharmacodynamics of cefazolin in patients with a high body weight. Cefazolin was …

Abstract Background and Objective Tigecycline, a broad-spectrum glycylcycline antibiotic, is
approved for use at a fixed dose irrespective of body weight. However, its pharmacokinetics …

The prevalence of obesity has increased considerably in the last few decades.
Pathophysiological changes in obese patients lead to pharmacokinetic (PK) and …

Individuals with obesity are at increased risk of developing infectious diseases. Timely
administration of an effective dose of an antimicrobial agent is paramount to safeguard …

Introduction Cefazolin is the leading antibiotic used to prevent surgical site infections
worldwide. Consensus guidelines recommend adjustment of the cefazolin dose above and …