There is a rising worldwide prevalence of diabetes, especially type 2 diabetes mellitus (T 2
DM), which is one of the most challenging health problems in the 21st century. The …

Introduction: The thiazolidinedione (TZD) class of PPAR-γ ligands is predominantly known
for its insulin sensitization activity. Unfortunately, these drugs have discernible side effects at …

Two thiazolidinedione scaffolds different in the position of the thiazolidinedione ring in the
molecule were tested for in vitro cytotoxic activity in a panel of human cancer cell lines …

Probiotics with ability to produce conjugated linoleic acid (CLA) is considered as an additive
health benefit property for its known role in colon cancer mitigation. The conversion involves …

Daphne altaica Pall.(D. altaica; Thymelaeaceae) has long been used in traditional Kazakh
medicine for the treatment of cancer and respiratory diseases. Previous studies have …

Background Carotenoids have been found to play roles in the prevention and therapy of
some cancers which PPARγ was also discovered to be involved in. The present studies …

Peroxisome proliferator-activated receptor gamma (PPARγ) has been shown to play an
important role in the biological effects of carotenoids. The PPARγ-signaling pathway is …

The use of targeted cancer therapies in combination with conventional chemotherapeutic
agents and/or radiation treatment has increased overall survival of cancer patients …

It has been demonstrated that PPARγ agonists effectively inhibit proliferation, metastasis as
well as induce apoptosis in human cancer cell lines. In this study, twenty-two rosiglitazone …

Peroxisomes are indispensably involved as a central player in the metabolism of reactive
oxygen species, bile acids, ether phospholipids, very-long-chain, and branched-chain fatty …