Deplete and repeat: microglial CSF1R inhibition and traumatic brain injury

R Boland, ON Kokiko-Cochran - Frontiers in Cellular Neuroscience, 2024 - frontiersin.org
Traumatic brain injury (TBI) is a public health burden affecting millions of people. Sustained
neuroinflammation after TBI is often associated with poor outcome. As a result, increased …

Context is key: glucocorticoid receptor and corticosteroid therapeutics in outcomes after traumatic brain injury

MA Taylor, ON Kokiko-Cochran - Frontiers in Cellular Neuroscience, 2024 - frontiersin.org
Traumatic brain injury (TBI) is a global health burden, and survivors suffer functional and
psychiatric consequences that can persist long after injury. TBI induces a physiological …

Divergent spatial learning, enhanced neuronal transcription, and blood–brain barrier disruption develop during recovery from post-injury sleep fragmentation

ZM Tapp, C Ren, K Palmer, J Kumar, RR Atluri… - Neurotrauma …, 2023 - liebertpub.com
Traumatic brain injury (TBI) causes pathophysiology that may significantly decrease quality
of life over time. A major propagator of this response is chronic, maladaptive …

[HTML][HTML] Sleep fragmentation after traumatic brain injury impairs behavior and conveys long-lasting impacts on neuroinflammation

S Houle, Z Tapp, S Dobres, S Ahsan, Y Reyes… - Brain, Behavior, & …, 2024 - Elsevier
Traumatic brain injury (TBI) causes a prolonged inflammatory response in the central
nervous system (CNS) driven by microglia. Microglial reactivity is exacerbated by stress …

Neuroimmune Responses to Sleep Disturbances after Traumatic Brain Injury

Z Tapp - 2023 - rave.ohiolink.edu
Traumatic brain injury (TBI) is the leading cause of injury-induced disabilities that decrease
quality of life. Neuroinflammation propagated by immune cells like microglia causes or …

Single-Nucleus Multi-Omic Characterization of Age-Specific Effects of Traumatic Brain Injury in the Mouse Hippocampus

P Bhatia - 2022 - search.proquest.com
Traumatic brain injury (TBI) has been characterized as a silent epidemic with growing
incidence rates worldwide. Recently, single cell genomics has revealed multiple microglial …