GABAergic inhibition shapes the connectivity, activity and plasticity of the brain. A series of
exciting new discoveries provides compelling evidence that disruptions in a number of key …

Autism spectrum disorder (ASD) and schizophrenia (SCZ) are separate disorders, with
distinct clinical profiles and natural histories. ASD, typically diagnosed in childhood, is …

Human genetics strongly support the involvement of synaptopathy in psychiatric disorders.
However, trans-scale causality linking synapse pathology to behavioral changes is lacking …

Schizophrenia was initially defined as “dementia praecox” by E. Kraepelin, which implies
progressive deterioration. However, recent studies have revealed that early effective …

Abstract Autism Spectrum Disorder (ASD) is a severe and lifelong neurodevelopmental
disorder, with high social costs and a dramatic burden on the quality of life of patients and …

Autism Spectrum Disorder (ASD) is a complex condition with early childhood onset,
characterized by a set of common behavioral features. The etiology of ASD is not yet fully …

The underlying pathologies of psychiatric disorders, which cause substantial personal and
social losses, remain unknown, and their elucidation is an urgent issue. To clarify the core …

Copy number variations (CNVs) are implicated across many neurodevelopmental disorders
(NDDs) and contribute to their shared genetic etiology. Multiple studies have attempted to …

Psychiatric disorders are mental, behavioral or emotional disorders. These conditions are
prevalent, one in four adults suffer from any type of psychiatric disorders world-wide. It has …

Copy number variants (CNVs) at specific loci have been identified as important risk factors
for several neuropsychiatric disorders, such as schizophrenia, autism spectrum disorder …