Urate homeostasis in humans is a complex and highly heritable process that involves ie,
metabolic urate biosynthesis, renal urate reabsorption, as well as renal and extrarenal urate …

Urate is produced in the liver by the degradation of purines from the diet and nucleotide
turnover and excreted by the kidney and gut. The kidney is the major route of urate removal …

Hyperuricemia (HUA) affects human health and is involved in the pathogenesis of common
chronic diseases. Previous studies showed that Ganoderma lucidum extract lowered HUA in …

Hyperuricemia involves multiple complex metabolisms, but no study has conducted a
comprehensive analysis using human blood and urine metabolomics for hyperuricemia …

Background An elevated level of blood uric acid (UA) leads to serious damages to human
health. In clinic, xanthine oxidase inhibitor is commonly used to reduce uric acid production …

Ethnopharmacological relevance Simiao San (SmS), a famous traditional Chinese formula,
is clinically used to treat patients with hyperuricemia (HUA). However, its mechanism of …

Background The many studies revealing a connection between serum uric acid (SUA) and
dementia have reported conflicting results. This study sought to investigate the relations …

Background Gout is a crystal related arthropathy caused by monosodium urate deposition.
At present, the identification of appropriate treatments and new drugs to reduce serum uric …

Abstract NLRP3 (NOD-, LRR-and pyrin domain-containing protein 3), a member of the
nucleotide-binding domain (NOD) and leucine-rich repeat sequence (LRR) protein (NLR) …

Arthritis is a group of diseases characterized by joint pain, swelling, stiffness, and limited
movement. Osteoarthritis, rheumatoid arthritis, and gouty arthritis are the most common …