Abstract The interleukin (IL)-1 family of cytokines comprises 11 members, including 7 pro-
inflammatory agonists (IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) and 4 defined or …

(1) Background: Familial Mediterranean Fever (FMF) is the prototypal autoinflammatory
disease, characterized by recurrent bursts of neutrophilic inflammation.(2) Methods: In this …

Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory
disease (AID) affecting mainly the ethnic groups originating from Mediterranean basin. The …

Objective Familial Mediterranean fever (FMF) is refractory to colchicine prophylaxis in 10–
20% of patients. In a number of patient series, treatment with anakinra, an interleukin‐1 …

Abstract Background Familial Mediterranean Fever (FMF) is a hereditary autoinflammatory
syndrome characterized by recurrent serositis or arthritis attacks and, in some patients …

Familial Mediterranean fever (FMF) is the most frequent monogenic autoinflammatory
disease, and it is characterized by recurrent attacks of fever and polyserositis. The disease is …

Autoinflammatory diseases (AIDs) represent a rare and heterogeneous group of disorders
characterized by recurrent episodes of inflammation and a broad range of clinical …

Monogenic autoinflammatory diseases are rare conditions caused by genetic abnormalities
affecting the innate immunity. Previous therapeutic strategies had been mainly based on …

Introduction In 5%–10% of patients with familial Mediterranean fever (FMF), colchicine is not
effective in preventing inflammatory attacks. Another 5%–10% of patients are intolerant to …

Objectives Colchicine is the main treatment for FMF. Although a number of individuals with
FMF are intolerant/resistant to colchicine, there is no standard definition of colchicine …