Heterogeneous nuclear ribonucleoproteins (hnRNPs) belong to a complex family of RNA-
binding proteins that are essential to control alternative splicing, mRNA trafficking, synaptic …

Brain antigen-specific autoreactive T cells seem to play a key role in inducing inflammation
in the central nervous system (CNS), a characteristic feature of human multiple sclerosis …

Background and Objectives The factors that drive progression in multiple sclerosis (MS)
remain obscure. Identification of key properties of meningeal inflammation will contribute to …

Narcolepsy is a rare cause of hypersomnolence and may be associated or not with
cataplexy, ie sudden muscle weakness. These forms are designated narcolepsy-type 1 …

Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated enzyme-
CAS holds great promise for treating many uncured human diseases and illnesses by …

Circulating T cells, which migrate from the periphery to sites of tissue inflammation, play a
crucial role in the development of various chronic inflammatory conditions. Recent research …

Amoeboid cell migration is key to efficient T cell immunity. Spatial polarization of organelles
within cells, including endo-lysosomes, is a prerequisite of migration. However, how …

Regulatory T-cells (Tregs) maintain immune homeostasis, but antigens activating adaptive
Tregs in human pathologies are ill-defined. EOMES+ type-1 regulatory (EOMES+ Tr1-like) T …

Phosphoinositides (PIs) are minor but essential phospholipids that play crucial roles in
cellular signaling pathways, membrane dynamics, and the regulation of various cellular …

The degenerative nature of Alzheimer's disease (AD) and its severe effects on cognitive
function present a major challenge to worldwide healthcare systems. CRISPR/Cas9, one of …