Targeting the mitochondria in chronic respiratory diseases

DK Chellappan, KR Paudel, NW Tan, KS Cheong… - Mitochondrion, 2022 - Elsevier
Mitochondria are one of the basic essential components for eukaryotic life survival. It is also
the source of respiratory ATP. Recently published studies have demonstrated that …

Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease

G De Rubis, KR Paudel, L Corrie, S Mehndiratta… - Naunyn-Schmiedeberg's …, 2023 - Springer
Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are among the
leading causes of mortality worldwide. Cigarette smoking is among the main aetiologic …

Agarwood oil nanoemulsion attenuates cigarette smoke-induced inflammation and oxidative stress markers in BCi-NS1. 1 airway epithelial cells

G De Rubis, KR Paudel, B Manandhar, SK Singh… - Nutrients, 2023 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is an irreversible inflammatory respiratory
disease characterized by frequent exacerbations and symptoms such as cough and …

Oxidative stress and air pollution: its impact on chronic respiratory diseases

MP Sierra-Vargas, JM Montero-Vargas… - International Journal of …, 2023 - mdpi.com
Redox regulation participates in the control of various aspects of metabolism. Reactive
oxygen and nitrogen species participate in many reactions under physiological conditions …

Nafamostat has anti-asthmatic effects associated with suppressed pro-inflammatory gene expression, eosinophil infiltration and airway hyperreactivity

VSRR Allam, I Waern, S Taha, S Akula… - Frontiers in …, 2023 - frontiersin.org
Introduction Asthma is characterized by an imbalance between proteases and their
inhibitors. Hence, an attractive therapeutic option could be to interfere with asthma …

Tackling the cytokine storm using advanced drug delivery in allergic airway disease

VK Patel, S Vishwas, R Kumar, G De Rubis… - Journal of Drug Delivery …, 2023 - Elsevier
Asthma is one of the leading causes of mortality worldwide presenting a huge socio-
economic burden with rising morbidity and mortality rates. It is a chronic inflammatory airway …

Dissecting the in vitro fate of plant-derived bioactive encapsulated nanoparticles in lung diseases

AB Saeid, VK Patel, S Mehndiratta, R Rajput… - Food Bioscience, 2023 - Elsevier
Lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), and lung
cancer are prevalent worldwide, with high mortality rates. There are many pathways …

Agarwood oil nanoemulsion counteracts LPS-induced inflammation and oxidative stress in RAW264. 7 mouse macrophages

R Malik, KR Paudel, B Manandhar, G De Rubis… - … -Research and Practice, 2023 - Elsevier
Purpose Oxidative stress and inflammation are key pathophysiological features of chronic
respiratory diseases, including asthma and chronic obstructive pulmonary disease (COPD) …

Seleno-metabolites and their precursors: a new dawn for several illnesses?

C Morán-Serradilla, E Angulo-Elizari… - Metabolites, 2022 - mdpi.com
Selenium (Se) is an essential element for human health as it is involved in different
physiological functions. Moreover, a great number of Se compounds can be considered …

Plant-based therapeutics for chronic obstructive pulmonary diseases: Nanoformulation strategies to overcome delivery challenges

S Kokkinis, M Singh, KR Paudel, G De Rubis, AB Saeid… - Food Bioscience, 2024 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a widespread global health problem
marked by increasing airflow limitation and chronic airway inflammation. Conventional …