This review highlights the influence of oxygen (O2) availability on cerebral blood flow (CBF).
Evidence for reductions in O2 content (CaO2) rather than arterial O2 tension (PaO2) as the …

Cellular hypoxia is the common final pathway of brain injury that occurs not just after
asphyxia, but also when cerebral perfusion is impaired directly (eg, embolic stroke) or …

1 History 1 2 The atmosphere 16 3 Geography and the human response to altitude 28 4
Genetics and high altitude 40 5 Altitude acclimatization and deterioration 53 6 Control of …

Respiratory‐induced changes in the partial pressures of arterial carbon dioxide and oxygen
play a major role in cerebral blood flow (CBF) regulation. Elevations in (hypercapnia) lead to …

Abstract Ainslie, Philip N., and Andrew W. Subudhi. Invited Review: Cerebral blood flow at
high altitude. High Alt Med Biol. 15: 133–140, 2014.—This brief review traces the last 50 …

This review discusses the impact of recent publications on pathophysiologic concepts and
on practical aspects of acute mountain sickness (AMS). Magnetic resonance imaging …

Ascent to high-altitude elicits compensatory physiological adaptations in order to improve
oxygenation throughout the body. The brain is particularly vulnerable to the hypoxemia of …

We examined the relationship between changes in cardiorespiratory and cerebrovascular
function in 14 healthy volunteers with and without hypoxia [arterial O2 saturation (SaO2)∼ …

Non‐technical summary Brain blood flow increases during the first week of living at high
altitude. We do not understand completely what causes the increase or how the factors that …

The regulation of cerebral blood flow (CBF) is a complex process that is altered significantly
with altitude exposure. Acute exposure produces a marked increase in CBF, in proportion to …