Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies
AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …
aging population worldwide. The enormous challenge which AD possesses to global …
Chalcone: A promising bioactive scaffold in medicinal chemistry
G Rajendran, D Bhanu, B Aruchamy, P Ramani… - Pharmaceuticals, 2022 - mdpi.com
Chalcones are a class of privileged scaffolds with high medicinal significance due to the
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …
presence of an α, β-unsaturated ketone functionality. Numerous functional modifications of …
Privileged scaffolds as MAO inhibitors: Retrospect and prospects
This review aims to be a comprehensive, authoritative, critical, and readable review of
general interest to the medicinal chemistry community because it focuses on the …
general interest to the medicinal chemistry community because it focuses on the …
Current pharmacotherapy and multi-target approaches for Alzheimer's disease
SL Cheong, JK Tiew, YH Fong, HW Leong, YM Chan… - Pharmaceuticals, 2022 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by decreased
synaptic transmission and cerebral atrophy with appearance of amyloid plaques and …
synaptic transmission and cerebral atrophy with appearance of amyloid plaques and …
Monoamine oxidase inhibitors: A concise review with special emphasis on structure activity relationship studies
Monoamine oxidase enzyme is necessary for the management of brain functions. It
oxidatively metabolizes monoamines and produces ammonia, aldehyde and hydrogen …
oxidatively metabolizes monoamines and produces ammonia, aldehyde and hydrogen …
Chalcones: Unearthing their therapeutic possibility as monoamine oxidase B inhibitors
In the last years the continuous efforts in the development of novel and effective inhibitors of
human monoamine oxidases (hMAOs) promoted the discovery of new agents able to …
human monoamine oxidases (hMAOs) promoted the discovery of new agents able to …
An insight into medicinal attributes of dithiocarbamates: Bird's eye view
Dithiocarbamates are considered as an important motif owing to its extensive biological
applications in medicinal chemistry. The synthesis of this framework can easily be achieved …
applications in medicinal chemistry. The synthesis of this framework can easily be achieved …
Development of bromo-and fluoro-based α, β-unsaturated ketones as highly potent MAO-B inhibitors for the treatment of Parkinson's disease
This study evaluated the synthesis of a dual series of bromo (CHB1–CHB4)-and fluoro
(CHF1–CHF4)-based α, β-unsaturated ketones and their inhibitory activities against …
(CHF1–CHF4)-based α, β-unsaturated ketones and their inhibitory activities against …
An ongoing journey of chalcone analogues as single and multi-target ligands in the field of Alzheimer's disease: A review with structural aspects
Alzheimer's disease (AD) is a chronic and irreversible neurodegenerative disorder with
progressive dementia and cognitive impairment. AD poses severe health challenge in …
progressive dementia and cognitive impairment. AD poses severe health challenge in …
Halogenated coumarin–chalcones as multifunctional monoamine oxidase-B and butyrylcholinesterase inhibitors
A series of halogenated coumarin–chalcones were synthesized, characterized, and their
inhibitory activities against monoamine oxidases (MAOs), acetylcholinesterase (AChE) …
inhibitory activities against monoamine oxidases (MAOs), acetylcholinesterase (AChE) …