During the last few decades, improvements in the planning and application of radiotherapy
in combination with surgery and chemotherapy resulted in increased survival rates of tumor …

Ionizing radiation, like a variety of other cellular stress factors, can activate or down-regulate
multiple signaling pathways, leading to either increased cell death or increased cell …

The threat of radiation-induced late normal tissue injury limits the dose of radiation that can
be delivered safely to cancer patients presenting with solid tumors. Tissue dysfunction and …

Diabetes is accompanied by several complications. Higher prevalence of cancers,
cardiovascular diseases, chronic kidney disease (CKD), obesity, osteoporosis, and …

Photodynamic therapy (PDT) is a cytotoxic treatment, which can induce cells to initiate a
rescue response, or to undergo cell death, either apoptosis or necrosis. The many signaling …

Radiation-induced apoptosis has been a topic of intense research during the last decade. Its
recognition as a significant component of radiation-induced cell death has initiated several …

One of the cornerstones of the web of signaling pathways governing cellular life and
differentiation is the DNA damage response. It spans a complex network of pathways …

Over the past 15 years, a wealth of information has been published on transcripts and
proteins 'induced'(requiring new protein synthesis) in mammalian cells after ionizing …

The DNA of all organisms is constantly subjected to damaging agents, both exogenous and
endogenous. One extremely harmful lesion is the double-strand break (DSB), which …

Embracing the transformation of radiation sciences by the recent surge of developments in
molecular biology, this progressive text offers an up-to-date analysis of in vitro and in vivo …