Smart contact lenses as wearable ophthalmic devices for disease monitoring and health management
The eye contains a complex network of physiological information and biomarkers for
monitoring disease and managing health, and ocular devices can be used to effectively …
monitoring disease and managing health, and ocular devices can be used to effectively …
Pathogenesis of glaucoma: Extracellular matrix dysfunction in the trabecular meshwork‐A review
KE Keller, DM Peters - Clinical & experimental ophthalmology, 2022 - Wiley Online Library
The trabecular meshwork regulates aqueous humour outflow from the anterior chamber of
the eye. It does this by establishing a tunable outflow resistance, defined by the interplay …
the eye. It does this by establishing a tunable outflow resistance, defined by the interplay …
Roles of exosomes in the normal and diseased eye
M Klingeborn, WM Dismuke, CB Rickman… - Progress in retinal and …, 2017 - Elsevier
Exosomes are nanometer-sized vesicles that are released by cells in a controlled fashion
and mediate a plethora of extra-and intercellular activities. Some key functions of exosomes …
and mediate a plethora of extra-and intercellular activities. Some key functions of exosomes …
CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of glaucoma
Background Glaucoma is a leading neurodegenerative disease affecting over 70 million
individuals worldwide. Early pathological events of axonal degeneration and retinopathy in …
individuals worldwide. Early pathological events of axonal degeneration and retinopathy in …
Crosstalk between MicroRNA and oxidative stress in primary open-angle glaucoma
S Tabak, S Schreiber-Avissar… - International journal of …, 2021 - mdpi.com
Reactive oxygen species (ROS) plays a key role in the pathogenesis of primary open-angle
glaucoma (POAG), a chronic neurodegenerative disease that damages the trabecular …
glaucoma (POAG), a chronic neurodegenerative disease that damages the trabecular …
Review of rodent hypertensive glaucoma models
Glaucoma is a neurodegenerative disease characterized by the progressive loss of retinal
ganglion cells (RGC s). Elevated intraocular pressure (IOP) is a primary risk factor for the …
ganglion cells (RGC s). Elevated intraocular pressure (IOP) is a primary risk factor for the …
Morphological and biomechanical analyses of the human healthy and glaucomatous aqueous outflow pathway: imaging-to-modeling
Abstract Background and Objective: Intraocular pressure (IOP) is maintained via a dynamic
balance between the production of aqueous humor and its drainage through the trabecular …
balance between the production of aqueous humor and its drainage through the trabecular …
Viscoelastic biomechanical properties of the conventional aqueous outflow pathway tissues in healthy and glaucoma human eyes
Background: Although the tissues comprising the ocular conventional outflow pathway have
shown strong viscoelastic mechanical response to aqueous humor pressure dynamics, the …
shown strong viscoelastic mechanical response to aqueous humor pressure dynamics, the …
Translational preclinical pharmacologic disease models for ophthalmic drug development
M Shah, S Cabrera-Ghayouri, LA Christie… - Pharmaceutical …, 2019 - Springer
Preclinical models of human diseases are critical to our understanding of disease etiology,
pathology, and progression and enable the development of effective treatments. An ideal …
pathology, and progression and enable the development of effective treatments. An ideal …
[HTML][HTML] Focus: drug development: novel pharmacologic candidates for treatment of primary open-angle glaucoma
LJ Lu, JC Tsai, J Liu - The Yale Journal of Biology and Medicine, 2017 - ncbi.nlm.nih.gov
Primary open-angle glaucoma (OAG) affects approximately 45 million people worldwide and
more than 2.5 million people aged 40 years or older in the United States. Pharmacologic …
more than 2.5 million people aged 40 years or older in the United States. Pharmacologic …