Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM)
remodeling endopeptidases that have the capacity to degrade almost every component of …

Type 2 diabetes mellitus (T2DM), accounting for 90–95% cases of diabetes, is characterized
by chronic inflammation. The mechanisms that control inflammation activation in T2DM are …

Kidney involvement confers significant morbidity and mortality in patients with systemic
lupus erythematosus (SLE). The pathogenesis of lupus nephritis (LN) involves diverse …

Pyroptosis is a type of programmed cell death, which has been associated with multiple
inflammatory diseases including diabetic atherosclerosis (DA). This study aims to explore …

Diabetic nephropathy (DN) is one of the most serious microvascular complications following
diabetes mellitus (DM). Ferulic acid (FA), a phenolic acid widely found in plants, has multiple …

The decrease in the podocyte's lifespan and health-span that typify healthy kidney aging
cause a decrease in their normal structure, physiology and function. The ability to halt and …

Kidney disease is worldwide the 12th leading cause of death affecting 8–16% of the entire
population. Kidney disease encompasses acute (short-lasting episode) and chronic …

Podocytes are critical for maintaining permselectivity of the glomerular filtration barrier, and
podocyte injury is a major cause of proteinuria in various primary and secondary …

Podocytes are epithelial cells adhering glomerular capillaries, which regulate the integrity of
glomerular filtration barrier. Irreversible podocyte injury induces glomerular inflammation …

The inflammasome is a multiprotein complex assembled by intracytoplasmic pattern
recognition receptors and is a key component of the innate immune system for host defense …