Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …

Matrix metalloproteinases (MMPs) are the major protease family responsible for the
cleavage of the matrisome (global composition of the extracellular matrix (ECM) proteome) …

In the tumour microenvironment, cancer cells directly interact with both the immune system
and the stroma. It is firmly established that the immune system, historically believed to be a …

Membrane-type matrix metalloproteases (MT-MMP) are pivotal regulators of cell invasion,
growth and survival. Tethered to the cell membranes by a transmembrane domain or GPI …

In solid tumours, cancer cells that undergo epithelial mesenchymal transition (EMT) express
characteristic gene expression signatures that promote invasive migration as well as the …

Invadopodia are cell protrusions that mediate cancer cell extravasation but the
microenvironmental cues and signaling factors that induce invadopodia formation during …

Metastasis—a process that involves the migration of cells from the primary site to distant
organs—is the leading cause of cancer-associated death. Improved technology and in …

Cholangiocarcinoma (CCA) is an aggressive tumour with a poor prognosis due to its late
clinical presentation and the lack of effective non-surgical therapies. Previous studies have …

Matrix remodeling plays central roles in a range of physiological and pathological processes
and is driven predominantly by the activity of matrix metalloproteinases (MMPs), which …

Background. Doublecortinlike kinase 1 (DCLK1) has been universally identified as a
cancer stem cell (CSC) marker and is found to be overexpressed in many types of cancers …