[HTML][HTML] Metformin beyond an anti-diabetic agent: A comprehensive and mechanistic review on its effects against natural and chemical toxins

A Malaekeh-Nikouei, S Shokri-Naei… - Biomedicine & …, 2023 - Elsevier
In addition to the anti-diabetic effect of metformin, a growing number of studies have shown
that metformin has some exciting properties, such as anti-oxidative capabilities, anticancer …

Exploring research gaps and trends in the management of acute phosphide poisoning: a systematic review

ZK Sobh, M Kholief, EK Sobh… - Critical reviews in …, 2023 - Taylor & Francis
Metal phosphides are highly toxic pesticides that result in high morbidities and mortalities
worldwide. This systematic review included 350 studies that fulfilled the eligibility criteria …

Synergistic strategies for enhanced liver cancer therapy with sorafenib/resveratrol PEGylated liposomes in vitro and in vivo

AA Alrashidi, SZ Alavi, M Koohi, A Raza… - Journal of Drug Delivery …, 2024 - Elsevier
This study investigates the therapeutic efficacy of sorafenib (Sr) and resveratrol (Rv)
encapsulated in liposomal formulations for liver cancer treatment. In vitro release profiles …

[HTML][HTML] Protective effects of empagliflozin on methotrexate induced hepatotoxicity in rats

E Kalantari, NM Zolbanin… - Biomedicine & …, 2024 - Elsevier
Methotrexate (MTX), a folic acid antagonist, is commonly prescribed as a cytotoxic drug to
treat several conditions such as leukemia and inflammation-related diseases, including …

Colorable role of interleukin (IL)-6 in obesity hypertension: A hint from a Chinese adult case-control study

O Wu, C Yuan, J Leng, X Zhang, W Liu, F Yang… - Cytokine, 2023 - Elsevier
Background Obesity and hypertension are major risk factors for cardiovascular diseases that
affect millions of people worldwide. Both conditions are associated with chronic low-grade …

Protective effects of empagliflozin on testicular injury induced by torsion/detorsion in adult male rats

MR Khezri, H Ghasemnejad-Berenji… - Journal of Pediatric …, 2023 - Elsevier
Introduction Testicular torsion is a known urologic emergency condition and one of the
common causes of infertility in males. Hence, prompt diagnosis and treatment play a crucial …

[HTML][HTML] Biochemical and histopathological evidence for beneficial effects of Empagliflozin pretreatment on acetic acid-induced colitis in rats

F Nazari-Khanamiri, A Jafari, Z Esmaeilzadeh… - BMC …, 2023 - Springer
Abstract Background Ulcerative Colitis (UC) is a disorder which oxidative stress plays a
critical role in its pathogenesis. Empagliflozin (EMPA) is a sodium-glucose cotransporter-2 …

Protective effects of sitagliptin on methotrexate-induced nephrotoxicity in rats

L Afkhami Fard, H Malekinejad… - … Science and Health …, 2023 - Taylor & Francis
Methotrexate (MTX), a cytotoxic chemotherapeutic and immunosuppressant agent, is widely
used in the treatment of autoimmune diseases and different types of cancers. However, its …

Screening alcohol degrading function probiotics and protective effect of fermented apple juice on alcoholic liver injury in mice

J Ren, S Yang, N Shen, X Wang, H Li, Y Chen, Z Gao - Food Bioscience, 2024 - Elsevier
In this study, we screened probiotics with alcohol degrading function and studied the
antioxidant activity of fermented apple juice and its protective effect on alcoholic liver injury …

Concomitant Effects of Metformin and Vitamin C on Indomethacin-Induced Gastric Ulcer in Rats: Biochemical and Histopathological Approach

MR Khezri, R Varzandeh… - Drug …, 2024 - thieme-connect.com
Introduction Gastric ulcer is one of the most common and serious conditions in the
gastrointestinal tract. One of the main causes of gastric ulcers is using of non-steroidal anti …