It is widely accepted that alterations to cyclooxygenase-2 (COX-2) expression and the
abundance of its enzymatic product prostaglandin E 2 (PGE 2) have key roles in influencing …

Tumor growth creates a hypoxic microenvironment, which promotes angiogenesis and
aggressive tumor growth and invasion. HIF1α is a central molecule involved in mediating …

Abstract Cyclooxygenase (COX)-2, the inducible key enzyme for prostanoid biosynthesis, is
overexpressed in most colorectal carcinomas and a subset of colorectal adenomas. Genetic …

The association between obesity and colorectal neoplasia may be mediated by
inflammation. Circulating levels of C-reactive protein (CRP), interleukin-6 (IL-6), and tumor …

Although the incidence of colorectal cancer (CRC) has been declining in recent decades, it
remains a major public health issue as a leading cause of cancer mortality and morbidity …

In the last two decades, research has dramatically increased the knowledge of cannabinoids
biology and pharmacology. In mammals, compounds with properties similar to active …

Colorectal cancer is a major cause of mortality and whilst up to 80% of sporadic colorectal
tumours are considered preventable, trends toward increasing obesity suggest the potential …

Epidemiology studies and clinical trials have suggested that the use of non-steroidal anti-
inflammatory drugs (NSAIDs), including aspirin, can significantly reduce the incidence of …

Abstract Cyclooxygenase-2 and prostaglandin E2 (PGE2) levels are increased in colorectal
cancers and a subset of adenomas. PGE2 signaling through the EP4 receptor has …

Colorectal cancer arises as a result of the accumulation of genetic errors many of which
affect the control of apoptosis. Effective chemoprevention strategies for colorectal cancer …