Natural killer (NK) cells possess potent perforin‐and interferon‐γ‐dependent effector
functions that are tightly regulated. Inhibitory receptors for major histocompatibility complex …

From the early days of natural killer (NK) cell research, it was clear that MHC genes
controlled the specificity of mouse NK cell-dependent responses, such as the ability to reject …

Cytotoxic lymphocytes fight pathogens and cancer by forming immune synapses with
infected or transformed target cells and then secreting cytotoxic perforin and granzyme into …

The relative contribution to cytotoxicity of each of the multiple NK cell activation receptors
has been difficult to assess. Using Drosophila insect cells, which express ligands of human …

Natural killer (NK) cells provide innate control of infected and neoplastic cells. Multiple
receptors have been implicated in natural cytotoxicity, but their individual contribution …

ICAMs are ligands for LFA-1, a major integrin of mononuclear cells involved in the immune
and inflammatory processes. We previously showed that endothelial cell specific molecule-1 …

Cytotoxicity of human NK cells is activated by receptors that bind ligands on target cells, but
the relative contribution of the many different activating and inhibitory NK cell receptors is …

DNAM-1 (CD226) is an activating receptor expressed on natural killer (NK) cells, CD8+ T
cells, and other immune cells. Upon recognition of its ligands, CD155 and CD112, DNAM-1 …

Despite the widespread use of the cell-surface receptor CD44 as a marker for antigen (Ag)-
experienced, effector and memory T cells, surprisingly little is known regarding its function …

During the innate immune response against infections, Natural Killer (NK) cells are as
important effector cells as are Cytotoxic T lymphocytes (CTL) generated after antigenic …