Complex and dynamic networks of molecules are involved in human diseases. High-
throughput technologies enable omics studies interrogating thousands to millions of makers …

Alzheimer's disease (AD) is characterized by non-linear, genetic-driven pathophysiological
dynamics with high heterogeneity in biological alterations and disease spatial-temporal …

Aging and neurodegenerative disease are characterized by genomic instability in neurons,
including aberrant activation and mobilization of transposable elements (TEs). Integrating …

There are currently no validated biomarkers which can be used to accurately diagnose
Alzheimer's disease (AD) or to distinguish it from other dementia-causing neuropathologies …

Alzheimer's disease (AD) is a chronic neurodegenerative disorder that is characterized by
progressive neuropathology and cognitive decline. We performed a cross-tissue analysis of …

The tauopathies constitute a group of diseases that have Tau inclusions in neurons or glia
as their common denominator. In this review, we describe the biochemical and histological …

In the embryonic and adult brain, neural stem cells proliferate and give rise to neurons and
glia through highly regulated processes. Epigenetic mechanisms—including DNA and …

As the discovery of the Alzheimer's disease (AD) genes, APP, PSEN1, and PSEN2, in
families with autosomal dominant early-onset AD (EOAD), gene discovery in familial EOAD …

Background There has been a steady increase in the number of studies aiming to identify
DNA methylation differences associated with complex phenotypes. Many of the challenges …

DNA methylation is critical for the normal development and functioning of the human brain,
such as the proliferation and differentiation of neural stem cells, synaptic plasticity, neuronal …