Importance Patient-reported outcomes are increasingly used as end points in clinical trials,
assessments in clinical care, and tools for population health, with an increasing role in …

The recommendations listed in this document are, whenever possible, evidence based. An
extensive evidence review was conducted as the document was compiled through …

Ranolazine which is currently approved as an antianginal agent reduces the Na-dependent
Ca overload via inhibition of the late sodium current (late INa) and thus improves diastolic …

Objectives: This study sought to examine the efficacy of ranolazine versus placebo on
weekly angina frequency and sublingual nitroglycerin use in subjects with type 2 diabetes …

Coronary artery disease (CAD) covers a wide spectrum from persons who are asymptomatic
to those presenting with acute coronary syndromes (ACS) and sudden cardiac death …

Background—As new techniques emerge to quantify patients' health status, new
opportunities are created to validate patient-reported outcome questionnaires. The Seattle …

Chronic angina is a common manifestation of ischaemic heart disease. Medical treatments
are the mainstay approach to reduce the occurrence of angina and improve patients' quality …

Background—Angina often persists or returns in populations following percutaneous
coronary intervention (PCI). We hypothesized that ranolazine would be effective in reducing …

The field of quality-of-life (QOL) measurement grew out of attempts in the 1960s and 1970s
to connect the ever-increasing levels of public expenditure on technology-based health care …

The voltage-gated cardiac sodium channel (Na v 1.5) is a mega-complex comprised of a
pore-forming α subunit and 4 ancillary β-subunits together with numerous protein partners …